大麻二酚、大麻二酚酸和大麻二酚酸甲酯作为止吐治疗的治疗潜力。
Therapeutic Potential of Cannabidiol, Cannabidiolic Acid, and Cannabidiolic Acid Methyl Ester as Treatments for Nausea and Vomiting.
机构信息
Collaborative Neuroscience Program, Department of Psychology, University of Guelph, Guelph, Ontario, Canada.
School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen, Scotland, United Kingdom.
出版信息
Cannabis Cannabinoid Res. 2021 Aug;6(4):266-274. doi: 10.1089/can.2021.0041. Epub 2021 Jun 11.
Abstract
Nausea and vomiting are the most distressing symptoms reported by oncology patients undergoing anticancer treatment. With the currently available treatments, vomiting and especially nausea remain problematic, highlighting the need for alternative treatments. Here we review and evidence for the effectiveness of the nonpsychoactive cannabinoid cannabidiol (CBD) in managing nausea and vomiting. In addition, we also review the evidence for CBD's acidic precursor, cannabidiolic acid (CBDA), and a methylated version of CBDA (CBDA-ME) in these phenomena. Finally, we explore the potential role of CBD in the treatment of cannabinoid hyperemesis syndrome. CBD has demonstrated efficacy in reducing nausea and vomiting, with CBDA and CBDA-ME being more potent. The data suggest a need for these compounds to be evaluated in clinical trials for their ability to reduce nausea and/or vomiting.
摘要
恶心和呕吐是接受癌症治疗的肿瘤患者报告的最令人痛苦的症状。目前可用的治疗方法，呕吐，尤其是恶心仍然是个问题，这突出表明需要替代治疗。在这里，我们回顾并评估了非精神活性大麻素大麻二酚（CBD）在管理恶心和呕吐方面的有效性。此外，我们还回顾了 CBD 的酸性前体大麻素酸（CBDA）和 CBDA 的甲基化版本（CBDA-ME）在这些现象中的证据。最后，我们探讨了 CBD 在治疗大麻素呕吐综合征中的潜在作用。 CBD 已被证明能有效减轻恶心和呕吐，而 CBDA 和 CBDA-ME 的效果更强。数据表明，需要对这些化合物进行临床试验，以评估它们减轻恶心和/或呕吐的能力。
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2
The effect of cannabidiol on canine neoplastic cell proliferation and mitogen-activated protein kinase activation during autophagy and apoptosis.
Vet Comp Oncol. 2021 Jun;19(2):253-265. doi: 10.1111/vco.12669. Epub 2021 Jan 14.
3
Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma.
Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
4
Cannabinoid Hyperemesis Syndrome: A Review of Potential Mechanisms.
Cannabis Cannabinoid Res. 2020 Jun 5;5(2):132-144. doi: 10.1089/can.2019.0059. eCollection 2020 Jun 1.
5
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Psychopharmacology (Berl). 2020 Sep;237(9):2621-2631. doi: 10.1007/s00213-020-05559-z. Epub 2020 Jun 2.
6
Adverse effects of cannabidiol: a systematic review and meta-analysis of randomized clinical trials.
Neuropsychopharmacology. 2020 Oct;45(11):1799-1806. doi: 10.1038/s41386-020-0667-2. Epub 2020 Apr 8.
7
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8
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9
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