棕榈酰辅酶A对心肌脂肪酶的抑制作用。

Inhibition of myocardial lipase by palmityl CoA.

作者信息

McDonough K H, Neely J R

机构信息

Department of Physiology, Louisiana State University Medical Center, New Orleans 70112.

出版信息

J Mol Cell Cardiol. 1988 Mar;20 Suppl 2:31-9. doi: 10.1016/0022-2828(88)90330-6.

DOI:10.1016/0022-2828(88)90330-6

PMID:3411615

Abstract

The lipase activity of the adult rat heart consists of at least two components; a lipoprotein lipase and a "hormone-sensitive" or triglyceride lipase. The control of the triglyceride lipase by intermediates of lipid metabolism was studied in rat heart homogenates. Perfusion of hearts with fatty acids, glucose or no exogenous substrate did not alter lipase activity. Bovine serum albumin (BSA) stimulated the in vitro lipase activity whereas palmityl-coenzyme A (CoA) was a potent inhibitor. Other fatty acid intermediates such as acetyl-CoA, acetyl-carnitine, palmityl-carnitine and palmitate had little or no effect. Long-chain acyl CoA may be an important intermediate for matching triglyceride hydrolysis with the supply of extracellular fatty acids and the rates of fatty acid oxidation.

摘要

成年大鼠心脏的脂肪酶活性至少由两个成分组成；一种脂蛋白脂肪酶和一种“激素敏感”或甘油三酯脂肪酶。在大鼠心脏匀浆中研究了脂质代谢中间体对甘油三酯脂肪酶的控制。用脂肪酸、葡萄糖或无外源底物灌注心脏不会改变脂肪酶活性。牛血清白蛋白（BSA）刺激体外脂肪酶活性，而棕榈酰辅酶A（CoA）是一种有效的抑制剂。其他脂肪酸中间体如乙酰辅酶A、乙酰肉碱、棕榈酰肉碱和棕榈酸酯几乎没有影响或没有影响。长链酰基辅酶A可能是使甘油三酯水解与细胞外脂肪酸供应及脂肪酸氧化速率相匹配的重要中间体。