Glina S, Reichelt A C, Leão P P, Dos Reis J M
Instituto H. Ellis, São Paulo, Brazil.
J Urol. 1988 Sep;140(3):523-4. doi: 10.1016/s0022-5347(17)41708-3.
Owing to the vasoconstrictive effect of nicotine, smoking may potentially interfere in the results of the drug-induced erection test for papaverine hydrochloride. To investigate the effect of smoking on this test, 12 patients between 22 and 65 years old underwent the following protocol: phase 1--intracavernous injection of 100 mg. papaverine hydrochloride with measurement of intracavernous pressure by puncture with a 19 caliber butterfly needle attached to an aneroid manometer and phase 2--1 week after the initial test the procedure was repeated after the patient smoked 2 cigarettes. In phase 1 all men obtained a full erection, compared to only 4 in phase 2. The average intracavernous pressures were 85.83 and 53.50 mm. Hg, respectively, in phases 1 and 2 (p less than 0.01). We conclude that cigarette smoking, probably through nicotine, interferes with the drug-induced erection test, which might explain some false negative results.
由于尼古丁的血管收缩作用，吸烟可能会干扰盐酸罂粟碱药物诱导勃起试验的结果。为了研究吸烟对该试验的影响，12名年龄在22至65岁之间的患者接受了以下方案：第一阶段——海绵体内注射100毫克盐酸罂粟碱，通过连接无液压力计的19号蝶形针穿刺测量海绵体内压力；第二阶段——在初次试验1周后，患者吸2支香烟后重复该操作。在第一阶段，所有男性均获得完全勃起，而在第二阶段只有4人获得完全勃起。第一阶段和第二阶段的平均海绵体内压力分别为85.83和53.50毫米汞柱（p<0.01）。我们得出结论，吸烟可能通过尼古丁干扰药物诱导勃起试验，这可能解释了一些假阴性结果。
