Foreyt W J, Gorham J R
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164.
J Wildl Dis. 1988 Jul;24(3):551-4. doi: 10.7589/0090-3558-24.3.551.
Praziquantel at dosages of 10, 20 or 100 mg/kg of body weight was evaluated against metacercariae of Nanophyetus salmincola in chinook salmon (Oncorhynchus tshawytscha). Ten salmon were used in each of four treated groups and 10 salmon were nontreated controls. Three wk after treatment, viability of metacercariae was determined by histologic evaluation, and by feeding the salmon to coyotes and subsequently determining the numbers of trematode eggs/g of feces and numbers of N. salmincola recovered at necropsy. Results of the experiment indicated that praziquantel at the dosages and routes of administration used was not effective against metacercariae in chinook salmon.
对奇努克鲑鱼（Oncorhynchus tshawytscha）体内的鲑居尾孢虫（Nanophyetus salmincola）囊蚴，评估了体重剂量为10、20或100 mg/kg的吡喹酮的效果。四个治疗组每组使用10条鲑鱼，10条鲑鱼作为未治疗的对照。治疗3周后，通过组织学评估、将鲑鱼喂给郊狼并随后确定每克粪便中的吸虫卵数量以及尸检时回收的鲑居尾孢虫数量来确定囊蚴的活力。实验结果表明，所用剂量和给药途径的吡喹酮对奇努克鲑鱼体内的囊蚴无效。
