Heisenberg Research Group, Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Lottestr. 55a, 22529, Hamburg, Germany.
Mildred Scheel Cancer Career Center Hamburg, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Curr Osteoporos Rep. 2021 Aug;19(4):391-402. doi: 10.1007/s11914-021-00686-8. Epub 2021 Jun 12.
We took an interdisciplinary view to examine the potential contribution of perilacunar/canalicular remodeling to declines in bone fracture resistance related to age or progression of osteoporosis.
Perilacunar remodeling is most prominent as a result of lactation; recent advances further elucidate the molecular players involved and their effect on bone material properties. Of these, vitamin D and calcitonin could be active during aging or osteoporosis. Menopause-related hormonal changes or osteoporosis therapies affect bone material properties and mechanical behavior. However, investigations of lacunar size or osteocyte TRAP activity with age or osteoporosis do not provide clear evidence for or against perilacunar remodeling. While the occurrence and potential role of perilacunar remodeling in aging and osteoporosis progression are largely under-investigated, widespread changes in bone matrix composition in OVX models and following osteoporosis therapies imply osteocytic maintenance of bone matrix. Perilacunar remodeling-induced changes in bone porosity, bone matrix composition, and bone adaptation could have significant implications for bone fracture resistance.
我们从跨学科的角度探讨了陷窝/小管重塑在与年龄相关或骨质疏松症进展相关的骨骨折抵抗力下降中的潜在贡献。
陷窝重塑最显著的结果是哺乳期；最近的进展进一步阐明了所涉及的分子参与者及其对骨材料特性的影响。其中，维生素 D 和降钙素在衰老或骨质疏松症期间可能具有活性。与绝经相关的激素变化或骨质疏松症治疗会影响骨材料特性和力学行为。然而，随着年龄的增长或骨质疏松症，对陷窝大小或破骨细胞 TRAP 活性的研究并未提供明确的证据支持或反对陷窝重塑。虽然陷窝重塑在衰老和骨质疏松症进展中的发生和潜在作用在很大程度上尚未得到充分研究，但 OVX 模型和骨质疏松症治疗后骨基质组成的广泛变化暗示了破骨细胞对骨基质的维持。陷窝重塑诱导的骨孔隙率、骨基质组成和骨适应的变化可能对骨骨折抵抗力有重要影响。
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