Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
J Cell Mol Med. 2021 Oct;25(19):9089-9101. doi: 10.1111/jcmm.16906. Epub 2021 Sep 6.
Osteoporosis is one bone disease characterized with skeletal impairment, bone strength reduced and fracture risk enhanced. The regulation processes of bone metabolism are associated with several factors such as mechanical stimulation, epigenetic regulation and hormones. However, the mechanism of osteoporosis remains unsatisfactory. Increasing high-throughput RNA sequencing and circular RNAs (circRNAs) microarray studies indicated that circRNAs are differentially expressed in osteoporosis. Growing functional studies further pinpointed specific deregulated expressed circRNAs (e.g., circ_28313, circ_0016624, circ_0006393, circ_0076906 and circ_0048211) for their functions involved in bone metabolism, including bone marrow stromal cells (BMSCs) differentiation, proliferation and apoptosis. Moreover, CircRNAs (circ_0002060, Circ_0001275 and Circ_0001445) may be acted as diagnostic biomarkers for osteoporosis. This review discussed recent progresses in the circRNAs expression profiling analyses and their potential functions in regulating BMSCs differentiation, proliferation and apoptosis.
骨质疏松症是一种骨骼疾病，其特征为骨骼损伤、骨强度降低和骨折风险增加。骨代谢的调节过程与机械刺激、表观遗传调控和激素等多种因素有关。然而，骨质疏松症的发病机制仍不尽人意。越来越多的高通量 RNA 测序和环状 RNA (circRNA) 微阵列研究表明，骨质疏松症中 circRNA 表达存在差异。进一步的功能研究还确定了特定的表达失调的 circRNA（如 circ_28313、circ_0016624、circ_0006393、circ_0076906 和 circ_0048211），它们参与骨代谢，包括骨髓基质细胞（BMSC）分化、增殖和凋亡。此外，circRNAs（circ_0002060、Circ_0001275 和 Circ_0001445）可能作为骨质疏松症的诊断生物标志物。本综述讨论了 circRNAs 表达谱分析的最新进展及其在调节 BMSC 分化、增殖和凋亡中的潜在功能。
