Chemistry&Biochemistry Laboratory, Department of Field and Vegetable Crops, Faculty of Agriculture, University of Novi Sad, Trg Dositeja Obradovića 8, 21000 Novi Sad, Serbia.
Department of Plant and Environmental Sciences, University of Copenhagen, Thorvaldsensvej 40, 1871 Frederiksberg C, Denmark.
Food Chem. 2021 Nov 15;362:130226. doi: 10.1016/j.foodchem.2021.130226. Epub 2021 Jun 2.
The focus of this study was to evaluate whether six choline chloride-based natural deep eutectic solvents (NADES) could serve as solvents for the extraction of bioactives from the leaves of Mentha piperita. NADES extracted significantly higher amounts of phenols from peppermint than 70% ethanol and may be useful in the extraction of targeted major compounds from peppermint, like rosmarinic acid, at a similar level as 70% ethanol. The microdilution method for in vitro antibacterial activity showed that all NADES exhibit bacterial growth inhibition at a lower concentration than 70% ethanol, especially NADESs containing organic acids. The majority of NADES extracts neutralize DPPH radical at a lower concentration than conventional solvent and showed similar ability to reduce Fe to Fe ions in FRAP assay. NADES can be useful in the isolation of phenolic compounds from plant sources and should be considered as novel, sustainable, and low-cost solvents with a variety of applications.
本研究的重点是评估六种基于氯化胆碱的天然深共晶溶剂（NADES）是否可作为从留兰香叶片中提取生物活性物质的溶剂。NADES 从薄荷中提取的酚类物质明显多于 70%乙醇，并且可能有助于从薄荷中提取目标主要化合物，如迷迭香酸，其水平与 70%乙醇相当。体外抗菌活性的微量稀释法表明，所有 NADES 的抑菌浓度均低于 70%乙醇，尤其是含有有机酸的 NADES。大多数 NADES 提取物在较低浓度下即可中和 DPPH 自由基，其还原能力与 FRAP 测定中传统溶剂相当。NADES 可用于从植物源中分离酚类化合物，应将其视为具有多种应用的新型、可持续且低成本的溶剂。
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