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约旦青少年特发性关节炎:单中心经验。

Juvenile idiopathic arthritis in Jordan: single center experience.

机构信息

Pediatric Immunology, Allergy and Rheumatology Division, Queen Rania Children's Hospital, Royal Medical Services, King Abdullah II St 226, P. O Box 11855, Amman, Jordan.

出版信息

Pediatr Rheumatol Online J. 2021 Jun 12;19(1):90. doi: 10.1186/s12969-021-00572-8.

Abstract

BACKGROUND

Juvenile idiopathic arthritis (JIA) is a heterogeneous group of disorders, including all forms of arthritis, which develops in children who are less than 16 years old. This study aimed to evaluate the clinical and laboratory features of JIA in a single center in Jordan.

METHODS

A retrospective analysis of the electronic medical records of Pediatric patients diagnosed with JIA based on the International League of Associations for Rheumatology (ILAR) criteria during the period from 2015 to 2019 at the Pediatric Rheumatology Clinic in the Queen Rania Children's Hospital. All patients were below the age of 14 years at the time of diagnosis and followed for at least 6 months. Collected data consisted of age, gender, age at initial presentation and diagnosis, JIA subtype, laboratory data, treatment options, and outcome.

RESULTS

A total of 210 patients were included in this cohort (94 males and 116 females) with the mean age at diagnosis and mean age at onset of 5.33 ± 3.40 years and 5.08 ± 3.40 years (range: 7 months - 14 years), respectively. Oligoarticular JIA was the commonest subtype (54.7%), followed by systemic arthritis (17.1%) and polyarticular arthritis (12.3%). ANA was positive in 70 patients (33.6%). Uveitis occurred in 30 (14.2%) patients.

CONCLUSION

To the best of our knowledge, this study on this cohort is the first report on JIA in Jordan, in comparison with other regionally and internationally published reports. Oligoarticular JIA was found to be the most common subtype. For detailed knowledge on JIA characteristics and patterns, a population-based, rather than a single center study, should be conducted in Jordan.

摘要

背景

幼年特发性关节炎(JIA)是一组异质性疾病,包括所有形式的关节炎,发生在 16 岁以下的儿童中。本研究旨在评估约旦单一中心 JIA 的临床和实验室特征。

方法

对 2015 年至 2019 年期间在 Queen Rania 儿童医院儿科风湿病诊所根据国际风湿病联盟(ILAR)标准诊断为 JIA 的儿科患者的电子病历进行回顾性分析。所有患者在诊断时均未满 14 岁,并至少随访 6 个月。收集的数据包括年龄、性别、初次就诊和诊断时的年龄、JIA 亚型、实验室数据、治疗选择和结果。

结果

本队列共纳入 210 例患者(94 例男性和 116 例女性),平均诊断年龄和平均发病年龄分别为 5.33±3.40 岁和 5.08±3.40 岁(范围:7 个月至 14 岁)。寡关节炎型 JIA 最常见(54.7%),其次是全身型关节炎(17.1%)和多关节炎型(12.3%)。70 例患者(33.6%)ANA 阳性。30 例(14.2%)患者发生葡萄膜炎。

结论

据我们所知,本研究是约旦关于 JIA 的首次报告,与其他地区和国际发表的报告相比。寡关节炎型 JIA 是最常见的亚型。为了详细了解 JIA 的特征和模式,应在约旦进行基于人群的研究,而不是单一中心的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ace/8196540/04d7526e421f/12969_2021_572_Fig1_HTML.jpg

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