Al-Hemairi Mohammad H, Albokhari Shatha M, Muzaffer Mohammed A
Department of General Pediatrics, Rabigh General Hospital, P.O. Box 51, Rabigh 21911, Saudi Arabia.
Department of Pediatrics, Division of Pediatric Rheumatology, King Abdulaziz University Hospital, P.O. Box. 80218, Jeddah 21589, Saudi Arabia.
Int J Inflam. 2016;2016:7802957. doi: 10.1155/2016/7802957. Epub 2016 Feb 7.
Introduction. Juvenile Idiopathic Arthritis (JIA) is the most common chronic arthritis in children. Our aim is to describe demographic, clinical, and laboratory characteristics and treatment of JIA patients followed up in Pediatric Rheumatology clinic in a tertiary center in Saudi Arabia. Methods. Medical records of all patients who are followed up between January 2007 and January 2015 were retrospectively reviewed. Data were collected about demographic, clinical, and laboratory features and treatment. Results. Total patients were 82, males were 31 (37.8%), and mean age of JIA onset was 7.1 ± 3.6 yr. Mean follow-up duration was 2.67±1.6 yr. Systemic onset JIA (SoJIA) was the commonest (36.5%), followed by polyarticular in 29.2% and oligoarticular in 28%. Large and small joints are involved in 76 (92%) and 30 (36.6%), respectively. Main extra-articular feature was fever in 34 (41.4%). Uveitis was diagnosed in 7 (8.5%) and in 5 (21.7%) of oligoarticular JIA. Anemia was found in 49 (59.7%), high ESR in 45 (54.8%), and leukocytosis and thrombocytosis in 33 (40.2%). Positive ANA was found in 30 (36.5%) mainly in oligoarticular subtype as 12 (52%) patients (out of 23) had this positive test. 9 patients (10.9%) required NSAIDs only, 6 patients (7.3%) required NSAIDs and intra-articular steroids only, and 19 (23%) required NSAIDs, methotrexate, steroids, and biologics. Conclusion. SoJIA is the most common JIA subtype in our study. A population based rather than a single center study will give more details about JIA characteristics in Saudi Arabia.
引言。幼年特发性关节炎(JIA)是儿童中最常见的慢性关节炎。我们的目的是描述在沙特阿拉伯一家三级中心的儿科风湿病诊所随访的JIA患者的人口统计学、临床和实验室特征以及治疗情况。方法。回顾性分析2007年1月至2015年1月期间所有随访患者的病历。收集有关人口统计学、临床和实验室特征以及治疗的数据。结果。患者总数为82例,男性31例(37.8%),JIA发病的平均年龄为7.1±3.6岁。平均随访时间为2.67±1.6年。全身型JIA(SoJIA)最为常见(36.5%),其次是多关节型,占29.2%,少关节型占28%。大关节和小关节受累的分别有76例(92%)和30例(36.6%)。主要关节外表现为发热,共34例(41.4%)。少关节型JIA患者中,7例(8.5%)被诊断为葡萄膜炎,5例(21.7%)也被诊断为葡萄膜炎。49例(59.7%)患者存在贫血,45例(54.8%)患者血沉升高,33例(40.2%)患者白细胞增多和血小板增多。30例(36.5%)患者抗核抗体呈阳性,主要集中在少关节型亚型,23例中有12例(52%)患者该项检查呈阳性。9例(10.9%)患者仅需使用非甾体抗炎药,6例(7.3%)患者仅需使用非甾体抗炎药和关节内注射类固醇,19例(23%)患者需要使用非甾体抗炎药、甲氨蝶呤、类固醇和生物制剂。结论。在我们的研究中,SoJIA是最常见的JIA亚型。基于人群而非单中心的研究将提供更多关于沙特阿拉伯JIA特征的详细信息。