Di Salvo Eleonora, Allegra Alessandro, Casciaro Marco, Gangemi Sebastiano
Department of Veterinary Sciences, University of Messina, 98168, Messina, Italy.
Division of Hematology, Department of Human Pathology in Adulthood and Childhood "Gaetano Barresi", University of Messina, 98125, Messina, Italy.
Clin Mol Allergy. 2021 Jun 12;19(1):8. doi: 10.1186/s12948-021-00148-7.
Pruritus is one of the most common symptoms experienced by neoplastic patients. The pathogenesis of neoplastic itch is complex and multifactorial and could be due to an unbalanced production of humoral mediators by altered immune effector cells. IL-31 is a pro-inflammatory cytokine produced by CD4 + T helper cells. The aim of this review was to evaluate the role of this Th2 cytokine and its receptor IL-31RA, in the onset of neoplastic pruritus. We analysed scientific literature looking for the most relevant original articles linking IL-31to itch in oncologic diseases. Interleukin-31 seems to be a main itch mediator in several hematologic disease such as Cutaneous T cells lymphomas. In these patients IL-31 was positively linked to itch level, and IL-31 matched with disease stage. IL-31 seems to play an important role in the signalling pathway involved in pruritus, but it is also suggested to play a proinflammatory and immunomodulatory role which could play a part in the progression of the neoplastic disease. Further studies will be fundamental in facing pruritus in oncologic patients, since this problem compromise their quality of life worsening an already critic picture.
瘙痒是肿瘤患者最常见的症状之一。肿瘤性瘙痒的发病机制复杂且多因素，可能是由于免疫效应细胞改变导致体液介质产生失衡。白细胞介素-31（IL-31）是一种由CD4 +辅助性T细胞产生的促炎细胞因子。本综述的目的是评估这种Th2细胞因子及其受体IL-31RA在肿瘤性瘙痒发病中的作用。我们分析了科学文献，寻找将IL-31与肿瘤疾病瘙痒联系起来的最相关原始文章。白细胞介素-31似乎是几种血液系统疾病（如皮肤T细胞淋巴瘤）中的主要瘙痒介质。在这些患者中，IL-31与瘙痒程度呈正相关，且IL-31与疾病分期相符。IL-31似乎在瘙痒相关的信号通路中起重要作用，但也有人认为它具有促炎和免疫调节作用，这可能在肿瘤疾病的进展中起作用。进一步的研究对于解决肿瘤患者的瘙痒问题至关重要，因为这个问题会降低他们的生活质量，使本已危急的情况更加恶化。
