Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.
Explore (NY). 2022 Jul-Aug;18(4):438-445. doi: 10.1016/j.explore.2021.05.003. Epub 2021 May 24.
Given the antioxidant properties of flaxseed and its biologically active ingredients, this study was conducted to determine the effects of flaxseed supplementation on body mass index (BMI), blood pressure, and total cholesterol levels in patients with hypertension.
In this triple-blind clinical trial, 112 patients, with an age range of 35 to 70 years, were randomized to 2 groups receiving 10 g (n = 45) and 30 g (n = 45) of flaxseed supplementation and 1 group receiving placebo (n = 45) for 12 weeks by stratified block randomization. They were evaluated in terms of systolic (SBP) and diastolic blood pressure (DBP), BMI, and total serum cholesterol. Physical activity was measured using the International Physical Activity Questionnaire-Short Form (IPAQ-SF) and food intake was assessed using the Food Frequency Questionnaire (FFQ). The data were analyzed with SPSS, version 22, using the chi-square, Kruskal-Wallis, repeated measures analysis, ANOVA, and ANCOVA tests.
The interaction effects among the study groups and time on the mean SBP (p = 0.001), DBP (p = 0.001), total cholesterol level (p = 0.032), and BMI (p < 0.001) were significant. During the study, the 30-g group achieved the best results, so that a 13.38-unit decrease in SBP was observed compared to a 1.72 unit increase in the placebo group and a 5.6-unit decrease in DBP was measured compared to a 2.39 unit increase in the placebo group. BMI decreased by 0.86 units compared to 0.06 units in the placebo group. Total cholesterol also decreased by 20.4 units compared to 11.86 units in the placebo group.
The results of this study showed that flaxseed can be effective in reducing blood pressure, total cholesterol, and body mass index in hypertensive patients in a twelve-week period.
鉴于亚麻籽具有抗氧化特性及其生物活性成分，本研究旨在确定亚麻籽补充剂对高血压患者的体重指数（BMI）、血压和总胆固醇水平的影响。
在这项三盲临床试验中，将 112 名年龄在 35 至 70 岁之间的患者随机分为两组，分别接受 10g（n=45）和 30g（n=45）亚麻籽补充剂和一组安慰剂（n=45），为期 12 周。通过分层块随机化进行分组。他们的收缩压（SBP）和舒张压（DBP）、BMI 和总血清胆固醇水平进行评估。采用国际体力活动问卷-短表（IPAQ-SF）测量体力活动，采用食物频率问卷（FFQ）评估食物摄入。采用 SPSS 22 版进行数据分析，采用卡方检验、克鲁斯卡尔-沃利斯检验、重复测量分析、方差分析和协方差分析。
研究组间和时间对平均 SBP（p=0.001）、DBP（p=0.001）、总胆固醇水平（p=0.032）和 BMI（p<0.001）的交互作用均有显著意义。在研究过程中，30g 组的效果最佳，与安慰剂组相比，SBP 降低了 13.38 个单位，而 DBP 降低了 5.6 个单位，安慰剂组分别增加了 1.72 个单位和 2.39 个单位。与安慰剂组相比，BMI 降低了 0.86 个单位，而安慰剂组增加了 0.06 个单位。总胆固醇也降低了 20.4 个单位，而安慰剂组增加了 11.86 个单位。
本研究结果表明，亚麻籽在 12 周内可有效降低高血压患者的血压、总胆固醇和体重指数。
