Hasan Refli, Saleh Raed Obaid, Raheema Rana H, Hulail Hanen Mahmod, Ahmad Irfan, Nathiya Deepak, Kaur Parjinder
Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.
Medical Laboratory Techniques Department, College of Health and Medical Technology, University of Al Maarif, Anbar, Iraq.
J Cardiovasc Thorac Res. 2025 Mar 18;17(1):1-11. doi: 10.34172/jcvtr.025.33280. eCollection 2025 Mar.
The prevalence rate of hypertension is on the rise at an alarming rate. Studies conducted on the influence of flaxseed on blood pressure (BP) have come up with conflicting conclusions. The current investigation's major purpose is to conduct a literature review and a meta-analysis focusing on the effect of flaxseed supplementation on BP in people with cardiovascular disease (CVD) risk factors. PubMed, Scopus, Web of Science, and Cochrane Central Library databases were searched from the inception date to April 2024 to find the randomized controlled trials (RCTs). A random-effects model combined the weighted mean difference (WMD). Standard methodologies were applied to evaluate publication bias, heterogeneity, and sensitivity analysis. Eighteen RCTs were included in the present systematic review and meta-analysis. Pooled analysis suggested that flaxseed supplementation can reduce systolic BP (SBP) (WMD: -4.75 mmHg, 95% CI: -7.05 to -2.44, ≤0.001; I=93.6%) and diastolic BP (DBP) (WMD: -3.09 mmHg, 95% CI: -4.37 to -1.81, ≤0.001; I=91.2%). In conclusion, the current meta-analysis has demonstrated that flaxseed supplementation can markedly lower BP in individuals exhibiting CVD risk factors. Given the significant heterogeneity, it is crucial to interpret the current results with careful consideration. In addition, further high-quality RCTs are required to better assess the causal relationships.
高血压的患病率正以惊人的速度上升。关于亚麻籽对血压（BP）影响的研究得出了相互矛盾的结论。当前调查的主要目的是进行一项文献综述和荟萃分析，重点关注补充亚麻籽对具有心血管疾病（CVD）风险因素人群血压的影响。从数据库建立之日至2024年4月，对PubMed、Scopus、科学网和Cochrane中央图书馆数据库进行检索，以查找随机对照试验（RCT）。采用随机效应模型合并加权平均差（WMD）。应用标准方法评估发表偏倚、异质性和敏感性分析。本系统评价和荟萃分析纳入了18项RCT。汇总分析表明，补充亚麻籽可降低收缩压（SBP）（WMD：-4.75 mmHg，95%CI：-7.05至-2.44，≤0.001；I²=93.6%）和舒张压（DBP）（WMD：-3.09 mmHg，95%CI：-4.37至-1.81，≤0.001；I²=91.2%）。总之，当前的荟萃分析表明，补充亚麻籽可显著降低具有CVD风险因素个体的血压。鉴于显著的异质性，谨慎解读当前结果至关重要。此外，需要进一步开展高质量的RCT，以更好地评估因果关系。
