Chemical constituents of two Cameroonian medicinal plants: L. and Burm. f. (Malvaceae) and their antiplasmodial activity.

An extensive phytochemical investigation of the EtOH/HO (7:3) extracts of L. and Burm. f., yielded a previously undescribed ceramide named rhombifoliamide () and a xylitol dimer (), naturally isolated here for the first time, as well as the thirteen known compounds , oleanolic acid (), -amyrin glucoside (), ursolic acid (), -sitosterol glucoside (), tiliroside (), 1,6-dihydroxyxanthone (), a mixture of stigmasterol () and -sitosterol (), cryptolepine (), 20-Hydroxyecdysone (), ()-suberenol (), thamnosmonin (1) and xanthyletin (1). Their structures were elucidated by the analyses of their spectroscopic and spectrometric data (1 D and 2 D NMR, and HRESI-MS) and by comparison with the previously reported data. The crude extracts, fractions, and some isolated compounds were tested against chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) strains. All the tested samples demonstrated moderate and/or significant activities against 3D7 (IC values: 0.18-20.11 µg/mL) and Dd2 (IC values: 0.74-63.09 µg/mL).[Formula: see text].