Karou Damintoti, Dicko Mamoudou H, Sanon Souleymane, Simpore Jacques, Traore Alfred S
Université de Ouagadougou, Centre de Recherche en Sciences Biologiques, Alimentaires et Nutritionnelles, Laboratoire de Biochimie, 03 BP 7131 Ouagadougou 03, Burkina Faso.
J Ethnopharmacol. 2003 Dec;89(2-3):291-4. doi: 10.1016/j.jep.2003.09.010.
Among strategies to combat malaria, the search for new antimalarial drugs appears to be a priority. Sheering for new antimalarial activities, four plants of the traditional medicine of Burkina Faso: Combretum micranthum, Khaya senegalensis, Pterocarpus erinaceus and Sida acuta, were tested in vitro on fresh clinical isolates of Plasmodium falciparum. The screening showed that Sida acuta has a significant activity (IC50 < 5 microg/ml), and Pterocarpus erinaceus has a moderate activity (5 microg/ml < IC50 < 50 microg/ml). Further chemical screening showed that the activity of the most active plant, Sida acuta, was related to its alkaloid contents.
在抗击疟疾的策略中，寻找新型抗疟药物似乎是当务之急。为筛选新的抗疟活性，对布基纳法索传统医学中的四种植物：小花风车子、塞内加尔桃花心木、刺猬紫檀和刺蒴麻，进行了恶性疟原虫新鲜临床分离株的体外测试。筛选结果表明，刺蒴麻具有显著活性（IC50 < 5微克/毫升），而刺猬紫檀具有中等活性（5微克/毫升 < IC50 < 50微克/毫升）。进一步的化学筛选表明，活性最强的植物刺蒴麻的活性与其生物碱含量有关。
