Tsybizova Alexandra, Roithová Jana
Department of Organic Chemistry, Charles University in Prague, Faculty of Science; Hlavova 2030, 128 40 Prague 2, Czech Republic.
Mass Spectrom Rev. 2016 Jan-Feb;35(1):85-110. doi: 10.1002/mas.21464. Epub 2015 May 14.
Electrospray ionization mass spectrometry (ESI-MS) is becoming an important tool for mechanistic studies in organic and organometallic chemistry. It allows investigation of reaction mixtures including monitoring of reactants, products, and intermediates, studying properties of the intermediates and their reactivity. Studying the reactive species in the gas phase can be advantageously combined with theoretical calculations. This review is focused on ESI-MS studies of copper-catalyzed reactions. Possible effects of the electrospray process on the transfer of the copper complexes to the gas phase are discussed. The plethora of mass spectrometric approaches is demonstrated on copper mediated C-H activations, cross coupling reactions, rearrangements, organocuprate chemistry, and other examples.
电喷雾电离质谱（ESI-MS）正成为有机化学和有机金属化学机理研究的重要工具。它可用于研究反应混合物，包括监测反应物、产物和中间体，研究中间体的性质及其反应活性。对气相中活性物种的研究可与理论计算有效结合。本综述聚焦于铜催化反应的ESI-MS研究。讨论了电喷雾过程对铜配合物转移至气相的可能影响。在铜介导的C-H活化、交叉偶联反应、重排反应、有机铜酸盐化学及其他实例中展示了大量的质谱方法。
