Physical Medicine and Rehabilitation Division, Umberto I University Hospital of Rome, Italy.
Unit of Physical Medicine and Rehabilitation, G. D' Annunzio University of Chieti-Pescara, Department of Oral Medical Science and Biotechnology (DSMOB), Chieti, Italy.
Biomed Res Int. 2021 Jun 1;2021:6664864. doi: 10.1155/2021/6664864. eCollection 2021.
The hypermobile type of Ehlers-Danlos syndrome (hEDS) is likely the most common hereditary disorder of connective tissue mainly characterized by joint hypermobility. Patients with hEDS suffer joint pain, in particular low back pain, commonly resistant to drug therapy. The aim of this research was to evaluate a neurocognitive rehabilitation approach based not only on the motion and function recovery but also on the pain management.
In this nonrandomized clinical trial, eighteen hEDS patients (4 males and 14 females) with mean age 21 years (range 13-55) were recruited and evaluated before and after three months of rehabilitation treatment.
The outcome scores showed significant statistical results after treatment in reducing pain symptoms (numerical rating scale, = 0.003; McGill (total score), = 0.03), fatigue (fatigue severity scale, = 0.03), fear of movement (Tampa scale, = 0.003), and pain-associated disability (Oswestry disability index, = 0.03).
The clinical results observed in our study seem to confirm the role of a specific neurocognitive rehabilitation program in the chronic pain management in the Ehlers-Danlos syndrome; the rehabilitation treatment should be tailored on patient problems and focused not only in the recovery of movement but also on pain perception.
Ehlers-Danlos 综合征（hEDS）的高活动型可能是最常见的结缔组织遗传性疾病，主要特征是关节过度活动。hEDS 患者会出现关节疼痛，特别是腰痛，通常对药物治疗有抗性。本研究的目的是评估一种神经认知康复方法，该方法不仅基于运动和功能恢复，还基于疼痛管理。
在这项非随机临床试验中，招募了 18 名 hEDS 患者（4 名男性和 14 名女性），平均年龄 21 岁（范围 13-55 岁），并在康复治疗前和治疗后三个月进行了评估。
治疗后，疼痛症状（数字评分量表， = 0.003；麦吉尔（总分）， = 0.03）、疲劳（疲劳严重程度量表， = 0.03）、运动恐惧（坦帕量表， = 0.003）和疼痛相关残疾（Oswestry 残疾指数， = 0.03）的评分结果均具有显著统计学意义。
我们的研究观察到的临床结果似乎证实了特定的神经认知康复方案在 Ehlers-Danlos 综合征慢性疼痛管理中的作用；康复治疗应根据患者的问题量身定制，不仅要注重运动的恢复，还要注重疼痛的感知。
