组胺诱发人内皮细胞胞质钙的重复性尖峰。
Repetitive spikes in cytoplasmic calcium evoked by histamine in human endothelial cells.
作者信息
Jacob R, Merritt J E, Hallam T J, Rink T J
机构信息
Smith Kline & French Research Limited, The Frythe, Welwyn, Hertfordshire, UK.
出版信息
Nature. 1988 Sep 1;335(6185):40-5. doi: 10.1038/335040a0.
DOI:10.1038/335040a0
PMID:3412458
Abstract
Measurement of cytoplasmic free calcium, [Ca2+]i, in single human endothelial cells has shown that low doses of the inflammatory mediator histamine evoke asynchronous repetitive spikes in [Ca2+]i whereas high doses cause a maintained elevated [Ca2+]i. We discuss possible regulatory mechanisms, and the potential physiological and pathological implications of such a frequency-modulated [Ca2+]i signalling system.
摘要
对单个人类内皮细胞中细胞质游离钙（[Ca2+]i）的测量表明，低剂量的炎症介质组胺会引发[Ca2+]i的异步重复尖峰，而高剂量则会导致[Ca2+]i持续升高。我们讨论了可能的调节机制，以及这种频率调制的[Ca2+]i信号系统的潜在生理和病理意义。
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