双（亚氨基）蒽衍生物作为G-四链体配体的合成与评价
Synthesis and evaluation of bis(imino)anthracene derivatives as G-quadruplex ligands.
作者信息
Coban Tomris, Robertson Cameron, Schwikkard Sianne, Singer Richard, LeGresley Adam
机构信息
LSP&C, SEC Faculty, Kingston University Kingston-upon-Thames KT1 2EE UK
出版信息
RSC Med Chem. 2021 Mar 26;12(5):751-757. doi: 10.1039/d0md00428f.
Abstract
The synthesis of a small number of bis(imino)anthracene derivatives is reported. They were evaluated NMR for binding efficacy to the G-quadruplex-forming oligonucleotide sequence (TTGGGTT) and show activity against the HeLa cancer cell line. These novel ligands are compared to previously synthesised G-quadruplex ligands that target telomeres and oncogenes.
摘要
报道了少量双（亚氨基）蒽衍生物的合成。通过核磁共振对它们与形成G-四链体的寡核苷酸序列（TTGGGTT）的结合效力进行了评估，并且它们对HeLa癌细胞系显示出活性。将这些新型配体与先前合成的靶向端粒和癌基因的G-四链体配体进行了比较。
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