Icahn School of Medicine at Mount Sinai Hospital, One Gustave Levy L. Place, Box 1070, New York, NY, 10029, USA.
Curr Oncol Rep. 2021 Jun 14;23(8):90. doi: 10.1007/s11912-021-01083-1.
The risks of developing cancer and dementia both increase with age, giving rise to the complex question of whether continued cancer screening for older dementia patients is appropriate. This paper offers a practice-based clinical approach to determine an answer to this challenging question.
There is no consensus on the prevalence of cancer and dementia as co-diagnoses. Persons with dementia are screened less often compared to those without dementia. There is significant literature focusing on screening in the geriatric population, but there is little evidence to support decision-making for screening for older patients with dementia. Given this lack of evidence, individualized decisions should be made in collaboration with patients and family caregivers. Four considerations to help guide this process include prognosis, behavioral constraints, cognitive capacity, and goals for care. Future research will be challenging due to variability of factors that inform screening decisions and the vulnerable nature of this patient population.
癌症和痴呆的发病风险均随年龄增长而增加,这就引出了一个复杂的问题,即对于老年痴呆症患者,是否应继续进行癌症筛查。本文提供了一种基于实践的临床方法,以解答这一具有挑战性的问题。
痴呆症和癌症同时诊断的患病率尚无共识。与没有痴呆症的人相比,痴呆症患者的筛查频率较低。有大量文献专注于老年人群的筛查,但几乎没有证据支持为老年痴呆症患者进行筛查的决策。鉴于缺乏证据,应与患者及其家属共同做出个体化决策。有四个考虑因素可以帮助指导这一过程,包括预后、行为约束、认知能力和护理目标。由于影响筛查决策的因素存在差异,以及该患者群体的脆弱性,未来的研究将具有挑战性。