Du Kui-Fang, Huang Xiao-Jie, Chen Chao, Kong Wen-Jun, Xie Lian-Yong, Dong Hong-Wei, Wei Wen-Bin
Department of Ophthalmology, Beijing Youan Hospital, Capital Medical University, Beijing, China.
Department of Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, China.
Ocul Immunol Inflamm. 2022 Oct-Nov;30(7-8):1559-1563. doi: 10.1080/09273948.2021.1905857. Epub 2021 Jun 14.
To clarify the cut off value of blood CMV load to indicate CMV retinitis and its relationships with ocular features.
Patients were divided into non-CMV and CMV retinitis groups. A logistic regression model was applied to estimate the association of each variable with CMV retinitis. Spearman correlation was used to estimate the correlation between the blood and aqueous CMV load.
Blood CMV load higher than 4log (OR, 6.897; CI: 2.813-16.910; < .001) was the major predictor of CMV retinitis. Blood CMV load wasn't different between the initial and early stage ( = .066). No correlation was observed between the blood and aqueous CMV load ( = .083, r = 0.228).
Blood CMV load higher than 4log is an important predictor for CMV retinitis in HIV/AIDS patients, but it couldn't indicate the ocular features. Ophthalmologic screening is still necessary.: CMV: Cytomegalovirus; CMVR: Cytomegalovirus retinitis; HIV: Human Immunodeficiency Virus; AIDS: Acquired Immune Deficiency Syndrome; ART: Antiretroviral therapy; EOD: End-organ diseases; PCR: Polymerase Chain Reaction; OR: Odds Ratio; CI: 95% Confidence Interval; IQR: Interquartile range.
明确血液巨细胞病毒（CMV）载量的截断值以指示CMV视网膜炎及其与眼部特征的关系。
将患者分为非CMV组和CMV视网膜炎组。应用逻辑回归模型评估各变量与CMV视网膜炎的关联。采用Spearman相关性分析评估血液和房水CMV载量之间的相关性。
血液CMV载量高于4log（比值比[OR]，6.897；95%置信区间[CI]：2.813 - 16.910；P <.001）是CMV视网膜炎的主要预测指标。血液CMV载量在初始阶段和早期之间无差异（P =.066）。血液和房水CMV载量之间未观察到相关性（P =.083，r = 0.228）。
血液CMV载量高于4log是HIV/AIDS患者CMV视网膜炎的重要预测指标，但不能指示眼部特征。眼科筛查仍然必要。：CMV：巨细胞病毒；CMVR：巨细胞病毒视网膜炎；HIV：人类免疫缺陷病毒；AIDS：获得性免疫缺陷综合征；ART：抗逆转录病毒疗法；EOD：终末器官疾病；PCR：聚合酶链反应；OR：比值比；CI：95%置信区间；IQR：四分位数间距。
