傅里叶变换红外光谱法研究两种结构相同的他汀类药物：辛伐他汀和洛伐他汀作为正品和药物。
FTIR spectroscopic study of two isostructural statins: Simvastatin and Lovastatin as authentic and in pharmaceuticals.
机构信息
Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, South Valley University, Qena 83523, Egypt.
Department of Pharmaceutical Analytical Chemistry, Unaizah College of Pharmacy, Qassim University, 5888 Unaizah, Saudi Arabia.
出版信息
Spectrochim Acta A Mol Biomol Spectrosc. 2021 Nov 15;261:120045. doi: 10.1016/j.saa.2021.120045. Epub 2021 Jun 3.
A very simple, economic analytical method with few sample pretreatment steps has been developed for quantitation of simvastatin in the presence of its isostructure lovastatin without any interference. It was utilized for easy and complete fine characterization of simvastatin FTIR spectrum from that of lovastatin. Simvastatin has been determined efficiently by the developed method either alone or in mixture with lovastatin giving LOQ values of 0.009 and 0.02% w/w, respectively indicating good sensitivity. Acceptable correlation coefficient values of 0.9975 and 0.9886 alone and in mixture with lovastatin, respectively. The developed spectroscopic method has provided simple and sensitive tool in quality control laboratories for efficient quantitation simvastatin in pharmaceutical tablets with good recoveries.
已经开发出一种非常简单、经济的分析方法，该方法预处理步骤很少，可在没有任何干扰的情况下定量存在其等结构洛伐他汀的辛伐他汀。它被用于轻松、完整地精细表征辛伐他汀的傅里叶变换红外光谱（FTIR），使其与洛伐他汀的光谱区分开来。所开发的方法可有效地单独测定辛伐他汀或与洛伐他汀混合测定，LOQ 值分别为 0.009 和 0.02%（w/w），表明灵敏度良好。单独使用和与洛伐他汀混合使用时，相关系数值分别为 0.9975 和 0.9886，均为可接受值。该光谱方法为质量控制实验室提供了一种简单、灵敏的工具，可用于高效定量药物片剂中的辛伐他汀，回收率良好。
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