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载辛伐他汀纳米纤维膜在修复跟腱中的效率。

Simvastatin-Loaded Nanofibrous Membrane Efficiency on the Repair of Achilles Tendons.

机构信息

Department of Orthopedic Surgery, Bone and Joint Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.

Department of Mechanical Engineering, Chang Gung University, Taoyuan, Taiwan.

出版信息

Int J Nanomedicine. 2022 Mar 16;17:1171-1184. doi: 10.2147/IJN.S353066. eCollection 2022.

DOI:10.2147/IJN.S353066
PMID:35321025
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8935736/
Abstract

INTRODUCTION

In this study, simvastatin-incorporated poly(D,L-lactide-co-glycolide) (PLGA) nanofibrous mats were fabricated via electrospinning, and their efficacy in the repair of the Achilles tendon was evaluated.

METHODS

The morphology of spun nanofibers and the in vitro drug release kinetics were assessed, while the in vivo efficacy in tendon repair was tested using a rat model.

RESULTS

Images obtained by scanning electron microscopy revealed that spun nanofibers exhibit a porous structure with a fiber diameter of approximately 350 nm. Fourier-transform infrared spectrometry and differential scanning calorimetry demonstrated successful incorporation of pharmaceutical agents into the PLGA nanofibers. The drug-loaded nanofibrous membranes sustainably discharged high concentrations of simvastatin for >28 days at the target site, and drug concentrations in blood were low. Tendons repaired using simvastatin-eluting nanofibers exhibited superior mechanical strength and animal activities to those repaired without nanofibers or with pure PLGA nanofibers.

DISCUSSION

Simvastatin-loaded nanofibers demonstrated effectiveness and sustainable capability for the repair of Achilles tendons. Eventually biodegradable drug-eluting nanofibrous mats may be used in humans for the treatment of tendon ruptures.

摘要

简介

本研究通过静电纺丝制备了载辛伐他汀的聚（D，L-丙交酯-共-乙交酯）（PLGA）纳米纤维垫，并评估了其在修复跟腱中的功效。

方法

评估了纺制纳米纤维的形态和体外药物释放动力学，并用大鼠模型测试了其在肌腱修复中的体内疗效。

结果

扫描电子显微镜图像显示，纺制的纳米纤维具有多孔结构，纤维直径约为 350nm。傅里叶变换红外光谱和差示扫描量热法表明药物已成功掺入 PLGA 纳米纤维中。载药纳米纤维膜在目标部位可持续释放超过 28 天的高浓度辛伐他汀，而血液中的药物浓度较低。用载辛伐他汀的纳米纤维修复的肌腱表现出优于未用纳米纤维或仅用纯 PLGA 纳米纤维修复的肌腱的机械强度和动物活动能力。

讨论

载辛伐他汀的纳米纤维在修复跟腱方面表现出有效性和可持续性。最终，可生物降解的载药纳米纤维垫可能会在人类中用于治疗肌腱断裂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a815/8935736/b94563892740/IJN-17-1171-g0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a815/8935736/2f3c08a953c6/IJN-17-1171-g0001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a815/8935736/ad0e53b8040a/IJN-17-1171-g0003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a815/8935736/d68ef1c9b23c/IJN-17-1171-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a815/8935736/949bcdfc26a4/IJN-17-1171-g0007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a815/8935736/b94563892740/IJN-17-1171-g0010.jpg

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