人催乳素分泌型垂体腺瘤中的钙调蛋白含量：与血清催乳素水平呈负相关。
Calmodulin content in human prolactin-secreting pituitary adenoma: an inverse relationship to serum prolactin levels.
作者信息
Bridges A J, Ho A K
机构信息
Department of Medicine, University of Wisconsin Hospital and Clinics, Madison.
出版信息
Neurosci Lett. 1988 Jul 19;90(1-2):224-8. doi: 10.1016/0304-3940(88)90816-6.
Calmodulin content was evaluated in 3 prolactin-secreting pituitary adenomas (prolactinoma) and 3 normal anterior pituitary glands. The calmodulin content in the normal anterior pituitary tissue was quite consistent, 3.32 +/- 0.016 micrograms/mg protein. In contrast, calmodulin content varied almost 4-fold in the prolactinoma tissue (10.97, 8.50 and 3.00 micrograms/mg protein). Preoperative serum prolactin levels varied inversely with the prolactinoma calmodulin content (125, 257 and 3526 ng/ml, respectively). This study reveals that prolactinoma calmodulin content differs from normal, although it is not uniformly elevated as in other transformed tissues and that elevation of prolactinoma calmodulin content does not positively correlate with serum prolactin levels.
对3例分泌催乳素的垂体腺瘤（催乳素瘤）和3个正常垂体前叶组织中的钙调蛋白含量进行了评估。正常垂体前叶组织中的钙调蛋白含量相当一致，为3.32±0.016微克/毫克蛋白质。相比之下，催乳素瘤组织中的钙调蛋白含量变化近4倍（分别为10.97、8.50和3.00微克/毫克蛋白质）。术前血清催乳素水平与催乳素瘤钙调蛋白含量呈负相关（分别为125、257和3526纳克/毫升）。这项研究表明，催乳素瘤的钙调蛋白含量与正常情况不同，尽管它不像其他转化组织那样普遍升高，而且催乳素瘤钙调蛋白含量的升高与血清催乳素水平没有正相关关系。
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