Schatz H, Daun M, Leicht R, Stracke H, Saeger W, Zierski J
Horm Res. 1985;21(4):246-53. doi: 10.1159/000180057.
A comparison was made with the data of 62 cases of pituitary adenoma, evaluated pre- and postoperatively, including as well the results of immunohistochemical hormone examination (also for calcitonin). Prolactin was found in 18 of the 21 adenomas carrying the preoperative diagnosis of prolactinoma, whereas cells containing other hormones (growth hormone, LH, FSH, TSH, ACTH, beta-endorphin), were only occasionally present. The growth hormone was strongly positive in the adenoma tissue in 16 of the 17 cases of acromegaly. 5 of these adenomas were accompanied by a marked hyperprolactinemia and also contained many prolactin cells. 6 of the 19 adenomas diagnosed as being 'inactive' contained hormone-positive cells, but only a very small number of cells. ACTH was found in 3 of the 4 pituitary adenomas of patients with Cushing's disease. 2 of these were also positive for beta-endorphin. The tissue of 1 gonadotrophic adenoma (with elevated FSH in serum) gave positive results with an anti-LH antiserum. Calcitonin was not found in any adenoma. The preoperative serum prolactin levels did not quantitatively correlate with the percentage of prolactin-positive cells.
对62例垂体腺瘤患者术前及术后的数据进行了比较，其中包括免疫组化激素检查（包括降钙素）的结果。在术前诊断为催乳素瘤的21例腺瘤中，有18例发现催乳素，而含有其他激素（生长激素、促黄体生成素、促卵泡生成素、促甲状腺激素、促肾上腺皮质激素、β-内啡肽）的细胞仅偶尔出现。在17例肢端肥大症患者的腺瘤组织中，16例生长激素呈强阳性。其中5例腺瘤伴有明显的高催乳素血症，且也含有许多催乳素细胞。在诊断为“无功能”的19例腺瘤中，有6例含有激素阳性细胞，但数量很少。在4例库欣病患者的垂体腺瘤中，有3例发现促肾上腺皮质激素。其中2例β-内啡肽也呈阳性。1例促性腺激素腺瘤（血清促卵泡生成素升高）的组织用抗促黄体生成素抗血清检测呈阳性结果。在任何腺瘤中均未发现降钙素。术前血清催乳素水平与催乳素阳性细胞的百分比无定量相关性。
