关于胃肠外铁剂Ferastral（一种铁-聚（山梨醇-葡萄糖酸）复合物）对人体血液凝固作用的研究。

Studies on the effect of parenteral iron, Ferastral, an iron-poly(sorbitol-gluconic acid) complex, on blood coagulation in man.

作者信息

Ploem J E, Jekel M

出版信息

Scand J Haematol Suppl. 1977;32:53-6. doi: 10.1111/j.1600-0609.1977.tb01215.x.

DOI:10.1111/j.1600-0609.1977.tb01215.x

Abstract

The possible influence of Ferastral, an iron-poly(sorbitol-gluconic acid) complex, on blood coagulation in man was investigated. Ferastral added to plasma produced no changes in blood coagulation until a final concentration of 2 000 microgram/ml (35.8 mmol/1) was used, when minimal changes in blood coagulation factors were observed. Five patients were given an intramuscular injection of 250 mg Ferastral. No changes in blood coagulation and thrombocyte function were observed up to 5 hours after the initial iron injection.

摘要

研究了铁-聚（山梨醇-葡萄糖酸）复合物Ferastral对人体血液凝固的可能影响。向血浆中添加Ferastral，直到使用终浓度为2000微克/毫升（35.8毫摩尔/升）时，血液凝固才出现微小变化，在此之前血液凝固无变化。对5名患者进行了250毫克Ferastral的肌肉注射。在首次注射铁剂后的5小时内，未观察到血液凝固和血小板功能的变化。