Department of Medical Biochemistry, Molecular Biology, and Immunology, University of Seville Medical School, Seville, Spain.
Superior Laboratory Technician, Department of External Analysis Service, IRNAS (CSIC) Seville, Seville, Spain.
Epidemiol Infect. 2021 Jun 16;149:e145. doi: 10.1017/S0950268821001333.
The appearance on the skin of herpes virus lesions, concomitantly with the coronavirus disease 2019 (COVID-19) pandemic, leads us to suspect an underlying infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Diagnostic reverse transcriptase polymerase chain reaction tests and immunoglobulin M (IgM) and IgG seroconversion studies have therefore been carried out. We present three cases of herpes virus infections in immunocompetent patients: one of the infections was herpes simplex 1 in a 40-year-old woman, and the other two were herpes varicella-zoster infections in a 62-year-old man and a 25-year-old woman. The patients were in the care of the southern health district of Seville of the SAS (Andalusian Health Service) during the Spanish state of alarm over the COVID-19 pandemic. The SARS-CoV-2 infection was confirmed in only one of the three cases. In this study, we briefly review the etiopathogenic role of the COVID-19 pandemic situation, whereby immunodeficiencies are generated that favour the appearance of other viral infections, such as herpes virus infections.
皮肤出现疱疹病毒病变，同时伴有 2019 年冠状病毒病（COVID-19）大流行，这使我们怀疑存在严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）的潜在感染。因此，已进行了诊断逆转录酶聚合酶链反应检测以及免疫球蛋白 M（IgM）和 IgG 血清转化研究。我们介绍了 3 例免疫功能正常的患者的疱疹病毒感染：1 例为 40 岁女性的单纯疱疹 1 型感染，另外 2 例为 62 岁男性和 25 岁女性的带状疱疹感染。在西班牙 COVID-19 大流行期间，这些患者在 SAS（安达卢西亚卫生服务局）南部卫生区接受治疗。在这 3 例病例中，仅在 1 例中确认了 SARS-CoV-2 感染。在这项研究中，我们简要回顾了 COVID-19 大流行情况的病因发病机制作用，由此产生的免疫缺陷有利于其他病毒感染（例如疱疹病毒感染）的出现。
