Koopmans P P, Thomas C M, van de Berg R J, Thien T, Gribnau F W
Department of Medicine, Sint Radboud Hospital, Catholic University Nijmegen, The Netherlands.
Prostaglandins Leukot Essent Fatty Acids. 1988 Jun;32(3):107-11.
Radioimmunoassay measurements of prostaglandins (PGs) E2, F2 alpha, 6-keto-PGF1 alpha and thromboxane (Tx) B2 in 24 h urine specimens from a male and a female healthy volunteer on several consecutive days revealed a dramatic increase of PGE2, PGF2 alpha, 6-keto-PGF1 alpha on days, upon which they had sexual intercourse; only TxB2 remained stable. Furthermore, the PGE2/PGF2 alpha ratio rose to values greater than 0.5 on days with sexual intercourse. This was found to be due to contamination of the urine samples by seminal fluid. Two 24 h urine samples from each of 26 healthy male and female volunteers (HV) revealed higher (p less than 0.01) mean PGE2 and PGF2 alpha values in males than in females. The results show that the interpretation of the urinary PG excretion as a measure of renal PG synthesis should be considered carefully, and that a PGE2/PGF2 alpha ratio greater than 0.5 indicates probable seminal contamination of urine.
对一名男性和一名女性健康志愿者连续数天的24小时尿液样本进行前列腺素（PGs）E2、F2α、6-酮-PGF1α和血栓素（Tx）B2的放射免疫分析测量发现，在他们发生性行为的日子里，PGE2、PGF2α、6-酮-PGF1α急剧增加；只有TxB2保持稳定。此外，在发生性行为的日子里，PGE2/PGF2α比值上升至大于0.5的值。发现这是由于精液污染了尿液样本所致。对26名健康男性和女性志愿者（HV）每人采集的两份24小时尿液样本显示，男性的平均PGE2和PGF2α值高于女性（p<0.01）。结果表明，将尿中PG排泄量作为肾脏PG合成量度的解释应谨慎考虑，且PGE2/PGF2α比值大于0.5表明尿液可能受到精液污染。
