通过自由基-极性交叉实现的光氧化还原催化苄基酯化反应
Photoredox-Catalyzed Benzylic Esterification via Radical-Polar Crossover.
作者信息
Maeda Bumpei, Sakakibara Yota, Murakami Kei, Itami Kenichiro
机构信息
Institute of Transformative Bio-Molecules (WPI-ITbM) and Graduate School of Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan.
Department of Chemistry, School of Science, Kwansei Gakuin University, 2-1 Gakuin, Sanda, Hyogo 669-1337, Japan.
出版信息
Org Lett. 2021 Jun 16. doi: 10.1021/acs.orglett.1c01645.
Photoredox-catalyzed C-O bond formation reactions are reported. The decarboxylative esterification reaction allows the conversion of a variety of arylacetic acids into the corresponding benzyl carboxylates. Furthermore, the use of (diacetoxyiodo)benzene allows the conversion of the benzylic C-H bond through hydrogen atom transfer. The reactions were applied to the divergent transformation of pharmaceuticals via decarboxylative or C-H esterification reactions.
报道了光氧化还原催化的C-O键形成反应。脱羧酯化反应可将多种芳基乙酸转化为相应的苄基羧酸盐。此外，使用（二乙酰氧基碘）苯可通过氢原子转移实现苄基C-H键的转化。这些反应通过脱羧或C-H酯化反应应用于药物的发散转化。
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