光氧化还原催化的芳基乙酸脱羧氧化反应。
Photoredox-Catalyzed Decarboxylative Oxidation of Arylacetic Acids.
机构信息
Institute of Transformative Bio-Molecules (WPI-ITbM) and Graduate School of Science, Nagoya University, Chikusa, Nagoya, 464-8602, Japan.
JST-ERATO, Itami Molecular Nanocarbon Project, Nagoya University, Chikusa, Nagoya, 464-8602, Japan.
出版信息
Chem Asian J. 2018 Sep 4;13(17):2410-2413. doi: 10.1002/asia.201800529. Epub 2018 May 30.
PMID:29696827
Abstract
A photoredox-catalyzed decarboxylative oxidation of arylacetic acids, which are privileged scaffolds in pharmaceuticals, is reported herein. The established method is operationally simple and a variety of substrates are applicable, providing rapid access to dehomologated bioisosteres of common pharmaceuticals.
摘要
本文报道了一种光氧化还原催化的芳基乙酸脱羧氧化反应，芳基乙酸是药物中一种重要的结构片段。该方法操作简单，具有广泛的底物适用性，可快速获得常见药物的去同系物生物等排体。
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