Division of Psychiatry, University College London, Maple House, 149 Tottenham Court Rd, London, W1T 7BN, UK.
Institute of Mental Health, University College London, London, UK.
BMC Med. 2021 Jun 17;19(1):133. doi: 10.1186/s12916-021-02007-3.
Sedentary behaviour is potentially a modifiable risk factor for depression and anxiety disorders, but findings have been inconsistent. To assess the associations of sedentary behaviour with depression and anxiety symptoms and estimate the impact of replacing daily time spent in sedentary behaviours with sleep, light, or moderate to vigorous physical activity, using compositional data analysis methods.
We conducted a prospective cohort study in 60,235 UK Biobank participants (mean age: 56; 56% female). Exposure was baseline daily movement behaviours (accelerometer-assessed sedentary behaviour and physical activity, and self-reported total sleep). Outcomes were depression and anxiety symptoms (Patient Health Questionnaire-9 and Generalised Anxiety Disorders-7) at follow-up.
Replacing 60 min of sedentary behaviour with light activity, moderate-to-vigorous activity, and sleep was associated with lower depression symptom scores by 1.3% (95% CI, 0.4-2.1%), 12.5% (95% CI, 11.4-13.5%), and 7.6% (95% CI, 6.9-8.4%), and lower odds of possible depression by 0.95 (95% CI, 0.94-0.96), 0.75 (95% CI, 0.74-0.76), and 0.90 (95% CI, 0.90-0.91) at follow-up. Replacing 60 min of sedentary behaviour with moderate-to-vigorous activity and sleep was associated with lower anxiety symptom scores by 6.6% (95% CI, 5.5-7.6%) and 4.5% (95% CI, 3.7-5.2%), and lower odds of meeting the threshold for a possible anxiety disorder by 0.90 (95% CI, 0.89-0.90) and 0.97 (95%CI, 0.96-0.97) at follow-up. However, replacing 60 min of sedentary behaviour with light activity was associated with higher anxiety symptom scores by 4.5% (95% CI, 3.7-5.3%) and higher odds of a possible anxiety disorder by 1.07 (95% CI, 1.06-1.08).
Sedentary behaviour is a risk factor for increased depression and anxiety symptoms in adults. Replacing sedentary behaviour with moderate-to-vigorous activity may reduce mental health risks, but more work is necessary to clarify the role of light activity.
久坐行为可能是抑郁和焦虑障碍的一个可改变的风险因素，但研究结果并不一致。为了使用成分数据分析方法评估久坐行为与抑郁和焦虑症状的关联，并估计用睡眠、轻度或中度至剧烈体力活动替代每天久坐行为时间的影响。
我们在英国生物库的 60235 名参与者中进行了一项前瞻性队列研究（平均年龄：56 岁；56%为女性）。暴露为基线日常运动行为（加速度计评估的久坐行为和体力活动以及自我报告的总睡眠时间）。随访时的结果是抑郁和焦虑症状（患者健康问卷-9 和广泛性焦虑障碍-7）。
用轻度活动、中到剧烈活动和睡眠代替 60 分钟的久坐行为，与抑郁症状评分降低 1.3%（95%CI，0.4-2.1%）、12.5%（95%CI，11.4-13.5%）和 7.6%（95%CI，6.9-8.4%）相关，与可能的抑郁的可能性降低 0.95（95%CI，0.94-0.96）、0.75（95%CI，0.74-0.76）和 0.90（95%CI，0.90-0.91）相关。用中到剧烈活动和睡眠代替 60 分钟的久坐行为与焦虑症状评分降低 6.6%（95%CI，5.5-7.6%）和 4.5%（95%CI，3.7-5.2%）相关，与可能的焦虑障碍的可能性降低 0.90（95%CI，0.89-0.90）和 0.97（95%CI，0.96-0.97）相关。然而，用轻度活动代替 60 分钟的久坐行为与焦虑症状评分升高 4.5%（95%CI，3.7-5.3%）和可能的焦虑障碍的可能性升高 1.07（95%CI，1.06-1.08）相关。
久坐行为是成年人抑郁和焦虑症状增加的一个风险因素。用中到剧烈活动代替久坐行为可能会降低心理健康风险，但需要进一步研究来澄清轻度活动的作用。
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