Ralph M R, Menaker M
Institute of Neuroscience, University of Oregon, Eugene 97403.
Science. 1988 Sep 2;241(4870):1225-7. doi: 10.1126/science.3413487.
A mutation has been found that dramatically shortens the period of the circadian locomotor rhythm of golden hamsters. The pattern of inheritance of this mutation suggests that it occurred at a single, autosomal locus (tau). Wild-type animals have rhythms with free-running periods averaging about 24 hours; animals heterozygous for the mutation have periods of about 22 hours, whereas homozygous animals have rhythms with periods close to 20 hours. Animals that carry the mutant alleles exhibit abnormal entrainment to 24-hour light:dark cycles or are unable to entrain.
已发现一种突变，该突变显著缩短了金黄仓鼠昼夜运动节律的周期。这种突变的遗传模式表明它发生在一个单一的常染色体位点（tau）。野生型动物的节律自由运行周期平均约为24小时；该突变的杂合动物周期约为22小时，而纯合动物的节律周期接近20小时。携带突变等位基因的动物对24小时明暗周期表现出异常的同步化或无法同步化。
