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Mesenchymal Stem Cells: An Excellent Candidate for the Treatment of Diabetes Mellitus.

作者信息

Huang Qiulan, Huang Yanting, Liu Jianping

机构信息

Department of Endocrinology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

出版信息

Int J Endocrinol. 2021 May 28;2021:9938658. doi: 10.1155/2021/9938658. eCollection 2021.

DOI:10.1155/2021/9938658
PMID:34135959
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8178013/
Abstract

Mesenchymal stem cells (MSCs) are adult stem cells (ASCs) known for repairing damaged cells, exerting anti-inflammatory responses and producing immunoregulatory effects that can be significantly induced into insulin-producing cells (IPCs), providing an inexhaustible supply of functional cells for cell replacement therapy and disease modeling for diabetes. MSC therapy may be the most promising strategy for diabetes mellitus because of these significant merits. In this paper, we focused on MSC therapy for diabetes.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c79/8178013/616c269b08dd/IJE2021-9938658.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c79/8178013/616c269b08dd/IJE2021-9938658.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c79/8178013/616c269b08dd/IJE2021-9938658.001.jpg

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[1]
Mesenchymal Stem Cells: An Excellent Candidate for the Treatment of Diabetes Mellitus.

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[7]
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[8]
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引用本文的文献

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Autologous and allogeneic mesenchymal stem cell-based therapies for diabetes mellitus: A systematic review and meta-analysis.

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[3]
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[4]
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[5]
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[6]
The Potential of Mesenchymal Stem Cell-Derived Exosomes to Treat Diabetes Mellitus.

Biomimetics (Basel). 2025-1-14

[7]
Stem cell therapy for type-2 diabetes: keeping the pedal to the metal to deliver translation to the clinic.

Expert Opin Biol Ther. 2024-11

[8]
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[9]
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[10]
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本文引用的文献

[1]
Mouse bone marrow-derived mesenchymal stem cells acquire immunogenicity concurrent with differentiation to insulin-producing cells.

Immunobiology. 2020-9

[2]
Comparison between the therapeutic effects of differentiated and undifferentiated Wharton's jelly mesenchymal stem cells in rats with streptozotocin-induced diabetes.

World J Stem Cells. 2020-2-26

[3]
Mesenchymal stem cells ameliorate β cell dysfunction of human type 2 diabetic islets by reversing β cell dedifferentiation.

EBioMedicine. 2020-1-6

[4]
Human Umbilical Cord-Derived Mesenchymal Stem Cell Therapy Ameliorates Nonalcoholic Fatty Liver Disease in Obese Type 2 Diabetic Mice.

Stem Cells Int. 2019-11-3

[5]
[The role of mesenchymal stem cells in allogeneic hematopoietic stem cell transplantation for patients with refractory severe aplastic anemia].

Zhonghua Xue Ye Xue Za Zhi. 2019-9-14

[6]
Decitabine assists umbilical cord-derived mesenchymal stem cells in improving glucose homeostasis by modulating macrophage polarization in type 2 diabetic mice.

Stem Cell Res Ther. 2019-8-19

[7]
Immune-Modulatory Changes After Transplantation Therapy of Insulin Producing Cells Derived from Wharton's Jelly Human Umbilical Cord-Mesenchymal Stem Cells in Diabetes Induced Rats.

Egypt J Immunol. 2019-1

[8]
Human Liver-Derived Stem Cells Improve Fibrosis and Inflammation Associated with Nonalcoholic Steatohepatitis.

Stem Cells Int. 2019-6-2

[9]
Short-Term Protocols to Obtain Insulin-Producing Cells from Rat Adipose Tissue: Signaling Pathways and In Vivo Effect.

Int J Mol Sci. 2019-5-18

[10]
Navigating Two Roads to Glucose Normalization in Diabetes: Automated Insulin Delivery Devices and Cell Therapy.

Cell Metab. 2019-3-5

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