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1
Concordant acute myeloblastic leukemia in identical twins treated with allogeneic transplantation from a younger HLA-identical sibling following a single apheresis procedure.同卵双胞胎中经单次采集程序后接受来自年轻 HLA 相合同胞的异基因移植治疗的一致性急性髓细胞白血病。
Int J Hematol Oncol. 2020 Nov 16;10(1):IJH32. doi: 10.2217/ijh-2020-0017.
2
Comparable outcomes among unmanipulated haploidentical, matched unrelated, and matched sibling donors in BU-based myeloablative hematopoietic stem cell transplantation for intermediate and adverse risk acute myeloid leukemia in complete remission: a single-center study.在基于 BU 的清髓性造血干细胞移植中，未处理的单倍体相合、匹配的无关供体和匹配的同胞供体在完全缓解的中危和高危急性髓系白血病中的结果相当：一项单中心研究。
Ann Hematol. 2021 Jun;100(6):1579-1591. doi: 10.1007/s00277-020-04355-1. Epub 2020 Nov 24.
3
Unmanipulated haplo-identical donor transplantation compared with identical sibling donor had better anti-leukemia effect for refractory/relapsed acute myeloid leukemia not in remission status.未处理的单倍体相合供者移植与同基因供者相比，对未缓解状态的难治/复发急性髓系白血病有更好的抗白血病效果。
Ann Hematol. 2020 Dec;99(12):2911-2925. doi: 10.1007/s00277-020-04283-0. Epub 2020 Oct 1.
4
Identical-twin bone marrow transplants for leukemia.用于治疗白血病的同卵双胞胎骨髓移植。
Ann Intern Med. 1994 Apr 15;120(8):646-52. doi: 10.7326/0003-4819-120-8-199404150-00004.
5
[Allogenic transplantation of hematopoietic stem cells in the treatment of children with high-risk acute leukemia].异基因造血干细胞移植治疗儿童高危急性白血病
Cas Lek Cesk. 1998 Jun 15;137(12):363-7.
6
Outcomes of hematopoietic stem cell transplantation from unmanipulated haploidentical versus matched sibling donor in patients with acute myeloid leukemia in first complete remission with intermediate or high-risk cytogenetics: a study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation.未经调控的单倍体相合与同胞相合供者造血干细胞移植治疗伴有中高危细胞遗传学异常的急性髓系白血病患者在首次完全缓解后的结果：来自欧洲血液和骨髓移植学会急性白血病工作组的一项研究。
Haematologica. 2018 Aug;103(8):1317-1328. doi: 10.3324/haematol.2018.189258. Epub 2018 May 10.
7
Related HLA-mismatched/haploidentical hematopoietic stem cell transplantation without in vitro T-cell depletion: observations of a single Chinese center.无关供者HLA错配/单倍型相合非体外去除T细胞的造血干细胞移植：单中心中国经验
Clin Transpl. 2011:237-45.
8
Outcome and Minimal Residual Disease Monitoring in Patients with t(16;21) Acute Myelogenous Leukemia Undergoing Allogeneic Hematopoietic Stem Cell Transplantation.伴有 t(16;21) 的急性髓系白血病患者接受异基因造血干细胞移植后的结局和微小残留病监测。
Biol Blood Marrow Transplant. 2018 Jan;24(1):163-168. doi: 10.1016/j.bbmt.2017.09.002. Epub 2017 Sep 20.
9
Prophylactic Donor Lymphocyte Infusion (DLI) Followed by Minimal Residual Disease and Graft-versus-Host Disease-Guided Multiple DLIs Could Improve Outcomes after Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Refractory/Relapsed Acute Leukemia.在难治/复发性急性白血病患者中，进行异基因造血干细胞移植后，采用预防供者淋巴细胞输注（DLI），随后进行微小残留病和移植物抗宿主病指导的多次 DLI，可改善预后。
Biol Blood Marrow Transplant. 2017 Aug;23(8):1311-1319. doi: 10.1016/j.bbmt.2017.04.028. Epub 2017 May 5.
10
Second allogeneic hematopoietic stem cell transplantation as treatment for leukemia relapsing following a first transplant.第二次异基因造血干细胞移植作为首次移植后复发白血病的治疗方法。
Bone Marrow Transplant. 2000 Jan;25(1):41-5. doi: 10.1038/sj.bmt.1702101.

本文引用的文献

1
Acute myeloid leukaemia at an early age: Reviewing the interaction between pesticide exposure and -rearrangement.早年急性髓系白血病：审视农药暴露与基因重排之间的相互作用
Ecancermedicalscience. 2017 Nov 30;11:782. doi: 10.3332/ecancer.2017.782. eCollection 2017.
2
Major Histocompatibility Mismatch and Donor Choice for Second Allogeneic Bone Marrow Transplantation.主要组织相容性不合与第二个异基因骨髓移植的供者选择。
Biol Blood Marrow Transplant. 2017 Nov;23(11):1887-1894. doi: 10.1016/j.bbmt.2017.07.014. Epub 2017 Jul 25.
3
Prognostic significance of flow-cytometry evaluation of minimal residual disease in children with acute myeloid leukaemia treated according to the AIEOP-AML 2002/01 study protocol.根据AIEOP-AML 2002/01研究方案治疗的急性髓系白血病患儿微小残留病的流式细胞术评估的预后意义
Br J Haematol. 2017 Apr;177(1):116-126. doi: 10.1111/bjh.14523. Epub 2017 Feb 27.
4
Haploidentical peripheral blood stem cell transplantation with posttransplant cyclophosphamide in children and adolescents with hematological malignancies.采用移植后环磷酰胺的单倍体相合外周血干细胞移植治疗儿童和青少年血液系统恶性肿瘤
Pediatr Blood Cancer. 2016 Nov;63(11):2033-7. doi: 10.1002/pbc.26131. Epub 2016 Jul 9.
5
The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia.2016 年版世界卫生组织髓系肿瘤和急性白血病分类。
Blood. 2016 May 19;127(20):2391-405. doi: 10.1182/blood-2016-03-643544. Epub 2016 Apr 11.
6
Effective collection of peripheral blood stem cells in children weighing 20 kilogram or less in a single large-volume apheresis procedure.在一次大容量单采过程中有效采集体重20千克或以下儿童的外周血干细胞。
J Clin Apher. 2015 Oct;30(5):281-7. doi: 10.1002/jca.21375. Epub 2014 Dec 30.
7
Infants with acute myeloid leukemia treated according to the Associazione Italiana di Ematologia e Oncologia Pediatrica 2002/01 protocol have an outcome comparable to that of older children.按照意大利儿科学血液学与肿瘤学协会2002/01方案治疗的急性髓系白血病婴儿，其治疗结果与大龄儿童相当。
Haematologica. 2014 Aug;99(8):e127-9. doi: 10.3324/haematol.2014.106526. Epub 2014 May 16.
8
Twin Mitochondrial Sequence Analysis.双胞胎线粒体序列分析
Mol Genet Genomic Med. 2013 Sep 1;1(3):174-186. doi: 10.1002/mgg3.20.
9
DNA methylation studies using twins: what are they telling us?利用双胞胎进行的DNA甲基化研究：它们告诉了我们什么？
Genome Biol. 2012 Oct 18;13(10):172. doi: 10.1186/gb-2012-13-10-172.
10
High success rate of hematopoietic cell transplantation regardless of donor source in children with very high-risk leukemia.高危白血病患儿无论供者来源如何，造血干细胞移植成功率均高。
Blood. 2011 Jul 14;118(2):223-30. doi: 10.1182/blood-2011-01-333070. Epub 2011 May 25.

同卵双胞胎中经单次采集程序后接受来自年轻 HLA 相合同胞的异基因移植治疗的一致性急性髓细胞白血病。

Concordant acute myeloblastic leukemia in identical twins treated with allogeneic transplantation from a younger HLA-identical sibling following a single apheresis procedure.

作者信息

Jimenez-Antolinez Yajaira Valentine, Gonzalez-Lopez Elias Eugenio, Ruiz Ileana Yazmín Velasco, Cantu-Moreno Marcela, Gomez-Almaguer David, Gonzalez-Llano Oscar

机构信息

Hematology Service, Hospital Universitario 'Dr. Jose E. Gonzalez', Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México.

出版信息

Int J Hematol Oncol. 2020 Nov 16;10(1):IJH32. doi: 10.2217/ijh-2020-0017.

DOI:10.2217/ijh-2020-0017
PMID:34136123
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8191650/
Abstract

A concordant leukemia is that which occurs in a pair of monozygotic twins; a similar genetic background suggests an monoclonal origin. We present the case of a pair of monozygotic infants with concordant acute myeloid leukemia who underwent a peripheral blood hematopoietic stem-cell transplant (HSCT) from a single, younger human leukocyte antigen-identical sibling donor, using a fractioned graft collected during only one apheresis procedure. Twin A relapsed at +456 and received a second haploidentical HSCT from his father, twin B has been in complete remission since the first HSCT. Both children are in complete remission and with negative minimal residual disease at +900 (after second transplant) and +1488, respectively.

摘要

一致性白血病是指发生在一对同卵双胞胎中的白血病；相似的遗传背景提示其起源为单克隆性。我们报告了一对患有一致性急性髓系白血病的同卵婴儿病例，他们接受了来自一名较年轻的、人类白细胞抗原完全相同的同胞供者的外周血造血干细胞移植（HSCT），移植所用的分离移植物仅通过一次单采过程采集。双胞胎A在+456天时复发，并接受了来自其父亲的第二次单倍体相合HSCT，双胞胎B自首次HSCT后一直处于完全缓解状态。两个孩子均处于完全缓解状态，在+900天（第二次移植后）和+1488天时，微小残留病分别为阴性。