Hu Chun, Salter Venzon Dawna, Lange Katja, Maathuis Annet, Bellmann Susann, Gellenbeck Kevin
Nutrilite Health Institute Buena Park CA USA.
TIM BV Zeist The Netherlands.
Food Sci Nutr. 2021 May 4;9(6):3289-3296. doi: 10.1002/fsn3.2295. eCollection 2021 Jun.
The release characteristics of a unique blend of carotenoid beadlets designed to increase bioavailability were tested using the dynamic gastrointestinal model TIM-1. Individual carotenoid bioaccessibility peaks were observed over approximately 3-4 hr in the order of lutein and zeaxanthin first, followed by lycopene, and then finally α- and β-carotene; when tested as a beadlet blend or when the beadlets were compressed into tablets. Bioaccessibility measurements of 7%-20% were similar to those previously reported in literature and comparable between the two formulations, beadlet blend and tablet formulations. Total recovery of carotenoids from all compartments ranged from 70% to 90% for all carotenoids, except lycopene where almost 50% was unrecoverable after digestion in the TIM system.
使用动态胃肠模型TIM-1测试了旨在提高生物利用度的独特类胡萝卜素微珠混合物的释放特性。在大约3-4小时内观察到单个类胡萝卜素的生物可及性峰值，顺序为首先是叶黄素和玉米黄质，其次是番茄红素，最后是α-胡萝卜素和β-胡萝卜素；无论是作为微珠混合物进行测试，还是将微珠压制成片剂进行测试。7%-20%的生物可及性测量结果与文献中先前报道的结果相似，并且在微珠混合物和片剂这两种制剂之间具有可比性。除了番茄红素在TIM系统中消化后几乎有50%无法回收外，所有类胡萝卜素在所有隔室中的总回收率在70%至90%之间。
