Fernandez-Bussy Sebastian, Abia-Trujillo David, Patel Neal M, Pascual Jorge M, Majid Adnan, Folch Erik E, Reisenauer Janani S
Division of Pulmonary, Allergy, Sleep Medicine & Respiratory Services Mayo Clinic Jacksonville FL USA.
Division of Thoracic Surgery and Interventional Pulmonology Beth Israel Deaconess Medical Center Boston MA USA.
Respirol Case Rep. 2021 Jun 11;9(7):e00794. doi: 10.1002/rcr2.794. eCollection 2021 Jul.
Bronchoscopy in thrombocytopenic patients remains a controversial topic as traditionally varying platelet thresholds have been stablished as "safe," ranging from 20,000 to 50,000. A lower threshold may be safe for a routine airway inspection with bronchoalveolar lavage but will be far from safe for more invasive interventions such as needle biopsy, transbronchial biopsy, or cryo-biopsy. Currently, a minimal platelet threshold during robotic-assisted bronchoscopy (RAB) has not been established. In addition, the absolute platelet number does not guarantee appropriate platelet function. The literature regarding the safety of bronchoscopy and its bleeding risk, considering broader and more functional tests such as thromboelastography (TEG), is also lacking. We present our RAB approach to safely sample lung nodules in a patient with thrombocytopenia. Our precautionary strategy for high-risk bleeding cases during RAB utilizing TEG and parallel flexible bronchoscopy with segmental balloon occlusion may be an appropriate technique to minimize bleeding risk.
对于血小板减少的患者,支气管镜检查仍然是一个有争议的话题,因为传统上已确定的“安全”血小板阈值各不相同,范围从20,000到50,000。较低的阈值对于支气管肺泡灌洗的常规气道检查可能是安全的,但对于更具侵入性的干预措施,如针吸活检、经支气管活检或冷冻活检,则远非安全。目前,尚未确定机器人辅助支气管镜检查(RAB)期间的最低血小板阈值。此外,血小板的绝对数量并不能保证适当的血小板功能。关于支气管镜检查安全性及其出血风险的文献,考虑到更广泛和更具功能性的检测,如血栓弹力图(TEG),也很缺乏。我们介绍了我们在一名血小板减少症患者中安全采集肺结节样本的RAB方法。我们在RAB期间针对高风险出血病例采用TEG以及并行的带有节段性球囊阻塞的柔性支气管镜检查的预防策略,可能是一种将出血风险降至最低的合适技术。