Hindawy Abdullah Rida, Daboul Baraa, Hanafi Ibrahem, Albitar Sami
Division of Nephrology, Department of Internal Medicine, Aleppo University Hospital, Faculty of Medicine, University of Aleppo, Aleppo, Syria.
Department of Internal Medicine, Faculty of Medicine, University of Aleppo, Aleppo, Syria.
Oxf Med Case Reports. 2020 Dec 28;2020(12):omaa122. doi: 10.1093/omcr/omaa122. eCollection 2020 Dec.
Autosomal dominant polycystic kidney disease (ADPKD) is a systemic disease characterized by the formation of multiple cysts in several organs. The formation of aneurysms accompanying this disease is being increasingly reported in the literature, and mutations in PKD-1 and PKD-2 are suspected in this etiology. Although the association between ADPKD and multiple coronary arteries aneurysms (CAA) was reported several times, we are presenting a case with the combination of ADPKD, multiple giant CAAs, abdominal aortic aneurysms and a suspected intracranial aneurysm, which has never been reported. The asymptomatic presentation of these multiple aneurysms might support the recommendations for further diagnostic investigations in these patients.
常染色体显性多囊肾病（ADPKD）是一种全身性疾病，其特征是多个器官中形成多个囊肿。文献中越来越多地报道了伴随这种疾病出现的动脉瘤形成情况，并且怀疑PKD - 1和PKD - 2的突变与这种病因有关。尽管ADPKD与多发性冠状动脉瘤（CAA）之间的关联已被多次报道，但我们现报告一例同时合并ADPKD、多发性巨大CAA、腹主动脉瘤以及疑似颅内动脉瘤的病例，此前从未有过此类报道。这些多发性动脉瘤的无症状表现可能支持对这些患者进行进一步诊断性检查的建议。
