Edahiro Yoko, Takaku Tomoiku, Suzuki Mario, Fukuda Yasutaka, Harada Sakiko, Kinoshita Shintaro, Inano Tadaaki, Shirane Shuichi, Hamano Yasuharu, Kondo Akihide, Komatsu Norio
Department of Hematology, Juntendo University School of Medicine, 2-1-1 Hongou, Bunkyoku, Tokyo, 113-8421, Japan.
Department of Neurosurgery, Juntendo University School of Medicine, 2-1-1 Hongou, Bunkyoku, Tokyo, 113-8421, Japan.
Leuk Res Rep. 2021 May 21;15:100249. doi: 10.1016/j.lrr.2021.100249. eCollection 2021.
We report about a 48-year-old woman diagnosed with primary central nervous system lymphoma (PCNSL). After chemotherapy and autologous stem cell transplantation, she presented with a continuous high-grade fever. Positron emission tomography-computed tomography revealed prominent hepatosplenomegaly and high diffuse uptake of 18F-fluorodeoxyglucose in the liver, spleen, and lungs. Intravascular large B-cell lymphoma (IVLBCL) was diagnosed using random skin biopsy. There were no symptoms of IVLBCL at the time of diagnosis of PCNSL. The histopathological features of PCNSL and IVLBCL were nearly similar. These findings suggest that IVLBCL was the recurrence of PCNSL rather than a separate entity.
我们报告了一名48岁被诊断为原发性中枢神经系统淋巴瘤（PCNSL）的女性。化疗和自体干细胞移植后，她出现持续高热。正电子发射断层扫描-计算机断层扫描显示明显的肝脾肿大，肝脏、脾脏和肺部有高度弥漫性的18F-氟脱氧葡萄糖摄取。通过随机皮肤活检诊断为血管内大B细胞淋巴瘤（IVLBCL）。在诊断PCNSL时没有IVLBCL的症状。PCNSL和IVLBCL的组织病理学特征几乎相似。这些发现表明IVLBCL是PCNSL的复发而非一个独立的实体。
