Centro de Investigação em Química da Universidade do Porto/Department of Chemistry & Biochemistry, Faculty of Sciences, University of Porto, Porto, 4169-007, Portugal.
Future Med Chem. 2021 Aug;13(15):1301-1309. doi: 10.4155/fmc-2021-0119. Epub 2021 Jun 17.
Alzheimer's and Parkinson's disease are the most prevalent neurodegenerative diseases and the leading causes of dementia worldwide. The etiology of these multifactorial pathologies is not completely known. The available therapeutic approaches can cause temporary relief of symptoms but cannot slow down their progression or cure them. Life-changing therapeutic solutions are urgently needed, as the number of people suffering from these pathologies has been increasing quickly over the last few decades. Several targets are being studied, and innovative approaches are being pursued to find new therapeutic options. This overview is focused on the most recent information regarding the paradigm of using multitarget compounds to treat both Alzheimer's and Parkinson's disease.
阿尔茨海默病和帕金森病是最常见的神经退行性疾病，也是全球痴呆症的主要病因。这些多因素病理的病因尚不完全清楚。现有的治疗方法可以暂时缓解症状，但不能减缓其进展或治愈它们。由于过去几十年这些疾病的患者人数迅速增加，因此迫切需要改变生活的治疗方法。正在研究多个靶点，并正在寻求创新方法来寻找新的治疗选择。本综述重点介绍了使用多靶点化合物治疗阿尔茨海默病和帕金森病的最新信息。
