Centro de Investigação em Química da Universidade do Porto/Department of Chemistry & Biochemistry, University of Porto, Porto, 4169-007, Portugal.
Departamento de Química Orgánica, Facultade de Farmacia, Universidade de Santiago de Compostela, Santiago de Compostela, 15782, Spain.
Future Med Chem. 2022 Jun;14(12):847-850. doi: 10.4155/fmc-2022-0077. Epub 2022 May 6.
Neurodegenerative diseases are one of the leading causes of death, disability and dependency worldwide. Since the etiology of these complex pathologies is not completely known, the available therapeutic options can only cause temporary relief of the symptoms, but cannot cure them. Life-changing therapeutic solutions are urgently needed, as the number of people suffering from these pathologies has been increasing quickly over the last few decades. Recent studies regarding the paradigm of using multitarget compounds to treat both Alzheimer's and Parkinson's diseases have been analyzed and included in the review entitled . This interview is based on this previously published overview, highlighting some of the most important aspects.
神经退行性疾病是全球范围内导致死亡、残疾和依赖的主要原因之一。由于这些复杂疾病的病因尚不完全清楚,因此可用的治疗选择只能暂时缓解症状,但不能治愈这些疾病。急需改变生活的治疗方法,因为在过去几十年中,患有这些疾病的人数一直在迅速增加。最近关于使用多靶标化合物治疗阿尔茨海默病和帕金森病的范例的研究已经进行了分析,并包含在题为的综述中。本次采访是基于这篇已发表的综述,重点介绍了一些最重要的方面。