一氧化碳是低氧诱导因子脯氨酰羟化酶结构域 2 的抑制剂。
Carbon Monoxide is an Inhibitor of HIF Prolyl Hydroxylase Domain 2.
机构信息
School of Chemical Sciences, The University of Auckland, Private Bag 92019, Victoria Street West, Auckland, 1142, New Zealand.
School of Biological Sciences, Victoria University of Wellington, PO Box 600, Wellington, 6140, New Zealand.
出版信息
Chembiochem. 2021 Aug 3;22(15):2521-2525. doi: 10.1002/cbic.202100181. Epub 2021 Jun 29.
Hypoxia-inducible factor prolyl hydroxylase domain 2 (PHD2) is an important oxygen sensor in animals. By using the CO-releasing molecule-2 (CORM-2) as an in situ CO donor, we demonstrate that CO is an inhibitor of PHD2. This report provides further evidence about the emerging role of CO in oxygen sensing and homeostasis.
缺氧诱导因子脯氨酰羟化酶结构域 2（PHD2）是动物中重要的氧传感器。本研究采用一氧化碳释放分子-2（CORM-2）作为原位 CO 供体，证明 CO 是 PHD2 的抑制剂。该研究进一步证实了 CO 在氧感应和稳态中的新作用。
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