Iakushev V S, Davydov V V
Ukr Biokhim Zh (1978). 1988 May-Jun;60(3):91-4.
The formation of ischemic myocardium necrosis is accompanied by a disturbance of respiratory and phosphorylating function in the cortex of cerebral hemispheres. In this case the most considerable changes are revealed with the use of alpha-ketoglutarate as an oxidation substrate. Inhibition of succinic acid oxidation arises only when the acute stage of the experiment comes to an end (by the 7th day). Development of ischemic myocardium necrosis after the endured stress results in deeper inhibition of mitochondrial respiration of cerebral hemispheres.
缺血性心肌坏死的形成伴随着大脑半球皮质呼吸和磷酸化功能的紊乱。在这种情况下，使用α-酮戊二酸作为氧化底物时会出现最显著的变化。仅在实验急性期结束时（第7天）才会出现琥珀酸氧化的抑制。承受应激后缺血性心肌坏死的发展导致大脑半球线粒体呼吸受到更深度的抑制。
