Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran.
Department of Chemistry, Faculty of Basic Sciences, Tehran Islamic Azad University, North Branch, Tehran, Iran.
J Trace Elem Med Biol. 2021 Dec;68:126761. doi: 10.1016/j.jtemb.2021.126761. Epub 2021 May 4.
Considering the affecting role of environmental factors including trace elements and heavy metals on the upper gastrointestinal (GI) cancers, there is paucity of empirical research in tissue evaluations.
The present study aimed to measure the tissue content of some trace elements and heavy metals such as zinc (Zn), chromium (Cr), manganese (Mn), tin (Sn), copper (Cu), aluminum (Al), lead (Pb), and iron (Fe) in esophagus and gastric cancerous tissues compared to the adjacent healthy tissues.
In a cross-sectional study, the aforementioned trace elements and heavy metals were evaluated among patients with esophagus and gastric cancers. During endoscopy, multiple samples were taken from cancerous lesions and the adjacent healthy tissues. The classic flame atomic absorption spectroscopy (FAAS) method was employed as the study framework.
Fifty patients with the mean age of 53.92 ± 8.73 were enrolled in the current study. Thirteen patients suffered from esophageal cancer and thirty-seven patients were afflicted with gastric cancer. The results revealed significant differences in the median concentrations of Zn, Cr, Sn and, Cu (P < 0.05) between the two groups. Although there were no significant changes in the tissue content in the esophageal samples, in the median concentrations of Zn, Cr and, Sn (P < 0.05) in gastric tissues, significant differences were observed. Further, the results indicated that gender enacted an affecting role in the level of some trace elements and heavy metals.
The tissue contents of some elements were altered in gastric and esophageal cancers; this difference may reflect the underlying mechanism of cellular changing during the tumorigenesis or direct exposure of these elements. It seems that under the shade of other coexisting risk factors, larger cohort studies are suggested to be conducted to investigate other probable aspects in this area of interest.
考虑到环境因素（包括微量元素和重金属）对上消化道（GI）癌症的影响作用，在组织评估方面的实证研究很少。
本研究旨在测量食管和胃癌组织与相邻健康组织中一些微量元素和重金属（如锌（Zn）、铬（Cr）、锰（Mn）、锡（Sn）、铜（Cu）、铝（Al）、铅（Pb）和铁（Fe））的组织含量。
在一项横断面研究中，评估了上述微量元素和重金属在食管和胃癌患者中的含量。在内镜检查过程中，从癌性病变和相邻的健康组织中采集多个样本。采用经典火焰原子吸收光谱法（FAAS）作为研究框架。
本研究共纳入 50 名平均年龄为 53.92 ± 8.73 岁的患者。其中 13 例患有食管癌，37 例患有胃癌。结果显示，两组之间 Zn、Cr、Sn 和 Cu 的中位数浓度存在显著差异（P < 0.05）。虽然食管样本的组织含量没有显著变化，但在胃癌组织中 Zn、Cr 和 Sn 的中位数浓度（P < 0.05）方面观察到显著差异。此外，结果表明性别对一些微量元素和重金属的水平有影响作用。
胃癌和食管癌组织中一些元素的组织含量发生了改变；这种差异可能反映了肿瘤发生过程中细胞变化的潜在机制或这些元素的直接暴露。在其他共存危险因素的阴影下，似乎需要进行更大的队列研究来调查该领域其他可能的方面。
