Zhou Chencong, Wu Kaihan, Gu Meng, Yang Yushang, Tu Jiatao, Huang Xuan
Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Front Oncol. 2025 Feb 20;15:1524182. doi: 10.3389/fonc.2025.1524182. eCollection 2025.
Gastric cancer (GC) remains one of the most common types of cancer, ranking fifth among cancer-related deaths worldwide. Chemotherapy is an effective treatment for advanced GC. However, the development of chemotherapy resistance, which involves the malfunction of several signaling pathways and is the consequence of numerous variables interacting, seriously affects patient treatment and leads to poor clinical outcomes. Therefore, in order to treat GC, it is imperative to find novel medications that will increase chemotherapy sensitivity and reverse chemotherapy resistance. Traditional Chinese medicine (TCM) has been extensively researched as an adjuvant medication in recent years. It has been shown to have anticancer benefits and to be crucial in enhancing chemotherapy sensitivity and reducing chemotherapy resistance. Given this, the mechanism of treatment resistance in GC is summed up in this work. The theoretical foundation for TCM as a sensitizer in adjuvant treatment of GC is established by introducing the primary signal pathways and possible targets implicated in improving chemotherapy sensitivity and reversing chemotherapy resistance of GC by TCM and active ingredients.
胃癌（GC）仍然是最常见的癌症类型之一，在全球癌症相关死亡中排名第五。化疗是晚期胃癌的有效治疗方法。然而，化疗耐药性的产生涉及多种信号通路的功能失调，是众多变量相互作用的结果，严重影响患者的治疗效果并导致不良的临床结局。因此，为了治疗胃癌，必须找到能够提高化疗敏感性并逆转化疗耐药性的新型药物。近年来，中药（TCM）作为辅助药物已得到广泛研究。研究表明，它具有抗癌作用，对于提高化疗敏感性和降低化疗耐药性至关重要。鉴于此，本文总结了胃癌治疗耐药的机制。通过介绍与中药及活性成分改善胃癌化疗敏感性和逆转化疗耐药性相关的主要信号通路和可能靶点，确立了中药作为胃癌辅助治疗增敏剂的理论基础。
