Department of Nutrition and Dietetics, Istanbul Sabahattin Zaim University, 34662 Istanbul, Turkey.
Scientific and Technological Research & Application Center, Karamanoğlu Mehmetbey University, 70100 Karaman, Turkey.
J Trace Elem Med Biol. 2022 Jul;72:126978. doi: 10.1016/j.jtemb.2022.126978. Epub 2022 Mar 25.
Gastrointestinal (GI) cancers are an important cause of the death rate in Turkey and in the world. Especially upper (esophageal and gastric) GI cancers are the leading types of cancer by 20-27% in Eastern Turkey. Trace elements are involved in many physiological and metabolic processes in the human body. Recent studies suggest that the increase or decrease of trace elements in the body may be related to the formation and development of many diseases such as cancers, diabetes mellitus and cardiovascular diseases etc. METHOD AND MATERIALS: In this study some trace elements; cadmium (Cd), cobalt (Co), Copper (Cu), iron (Fe), magnesium (Mg), manganese (Mn), nickel (Ni), lead (Pb), zinc (Zn) concentrations were investigated in the blood serums of esophageal, gastric and colon cancer patients and healthy controls in Van city area, an endemic upper (esophageal and gastric) GI region of Eastern Turkey. The analysis of the elements was realized with a flame atomic absorption spectrophotometer (FAAS). RESULTS: Mean serum levels of Cd and Ni in esophageal and gastric cancer patients were very significantly lower compared to controls (p < 0.001 and < 0.005). In addition, the mean serum Co level of esophageal cancer patients was very significantly lower than in controls and gastric cancer patients (p < 0.002). Also, the mean serum levels of Fe and Mn in all (esophageal, gastric and colon) cancer groups were very significantly lower than in controls (p < 0.001 and 0.002). Mean serum levels of Cu, Mg, Pb and Zn were not significantly different in all cancer patients compared to controls. CONCLUSION: We have detected the deficiency of five trace elements (Fe, Mn, Cd, Ni, Co) in esophageal, gastric and colon cancer patients. The deficiencies of trace elements may be due to malign over consumption of the nutrients and to the malnutrition of the advanced cancer patients. Nutritional therapy rich in trace elements should be considered as one of the strategies to fight against cancers.
胃肠道（GI）癌症是土耳其乃至全球死亡率的一个重要原因。特别是在土耳其东部，上胃肠道（食管和胃）癌症占主导地位，其发病率为 20-27%。微量元素参与人体许多生理和代谢过程。最近的研究表明，体内微量元素的增加或减少可能与癌症、糖尿病和心血管疾病等许多疾病的形成和发展有关。方法和材料：在这项研究中，我们研究了一些微量元素；血液血清中的镉（Cd）、钴（Co）、铜（Cu）、铁（Fe）、镁（Mg）、锰（Mn）、镍（Ni）、铅（Pb）、锌（Zn）浓度，这些元素在土耳其东部上胃肠道（食管和胃）高发地区的凡城地区的食管癌、胃癌和结肠癌患者及健康对照组中进行了检测。元素分析是用火焰原子吸收分光光度计（FAAS）进行的。结果：与对照组相比，食管癌和胃癌患者的血清 Cd 和 Ni 水平显著降低（p<0.001 和 <0.005）。此外，食管癌患者的血清 Co 水平也显著低于对照组和胃癌患者（p<0.002）。同样，所有（食管、胃和结肠）癌症组的血清 Fe 和 Mn 水平也显著低于对照组（p<0.001 和 0.002）。所有癌症患者的血清 Cu、Mg、Pb 和 Zn 水平与对照组相比均无显著差异。结论：我们检测到食管癌、胃癌和结肠癌患者有 5 种微量元素（Fe、Mn、Cd、Ni、Co）缺乏。微量元素的缺乏可能是由于恶性过度消耗营养物质和晚期癌症患者的营养不良。富含微量元素的营养治疗应被视为对抗癌症的策略之一。
