日粮亚硝酸盐和硝酸盐对口服磺胺二甲嘧啶的猪的代谢的影响。

The effect of dietary nitrite and nitrate on the metabolism of sulphadimidine administered orally to pigs.

作者信息

Hoogenboom L A, Pijpers A, van de Steeg P W, Aerts M M, Verheijden J H, Kuiper H A

机构信息

State Institute for Quality Control of Agricultural Products (RIKILT), Wageningen, The Netherlands.

出版信息

Vet Q. 1988 Apr;10(2):136-9. doi: 10.1080/01652176.1988.9694160.

DOI:10.1080/01652176.1988.9694160

PMID:3413971

Abstract

The in vivo interaction of sulphadimidine (SDM) with nitrite and nitrate has been investigated in pigs. It was shown that the combined oral treatment with SDM and nitrite but not nitrate leads to the formation of a deaminated compound, which becomes the major metabolite in plasma soon after cessation of the treatment. The major in vitro reaction product, 1,3-di(4-[N(4,6-dimethyl-2-pyrimidinyl)]-sulphamoylphenyl)-triazen e, DDPSPT as has been reported previously, could not be detected in blood, urine or faeces of the exposed animals. No effect of nitrite or nitrate could be observed on the acetylation of SDM.

摘要

已在猪身上研究了磺胺二甲嘧啶（SDM）与亚硝酸盐和硝酸盐的体内相互作用。结果表明，SDM与亚硝酸盐联合口服治疗可导致脱氨基化合物的形成，但与硝酸盐联合口服治疗则不会，该脱氨基化合物在治疗停止后不久即成为血浆中的主要代谢物。如先前报道的那样，主要的体外反应产物1,3 - 二（4 - [N（4,6 - 二甲基 - 2 - 嘧啶基）] - 氨磺酰基苯基） - 三氮烯（DDPSPT）在暴露动物的血液、尿液或粪便中未被检测到。未观察到亚硝酸盐或硝酸盐对SDM乙酰化的影响。