Mazo E L, Rusiaev V A, Fedorov A N, Iaroslavtseva N G, Kharitonenkov I G
Vopr Virusol. 1988 Mar-Apr;33(2):153-7.
The effect of matrix proteins (M proteins) of influenza A/MRC-11 and B/Lee viruses on oxidative phosphorylation in preparations of isolated mitochondria of white mice liver was studied. M proteins were shown to cause disorders in the system of oxidative phosphorylation leading to reduction of the coefficient of respiratory control and amplification coefficient recorded by the polarographic method. It was also shown that an anti-influenza compound 2-(1'-aminoethyl)-bicyclo(2.2.1)heptane hydrochloride reduced the damaging effect of influenza virus A/MRC-11 M protein but had no influence on the effect on mitochondrial respiration of influenza B/Lee virus M protein.
研究了甲型流感病毒A/MRC - 11和乙型流感病毒B/Lee的基质蛋白（M蛋白）对小白鼠肝脏离体线粒体制剂中氧化磷酸化的影响。结果表明，M蛋白会导致氧化磷酸化系统紊乱，致使极谱法记录的呼吸控制系数和放大系数降低。还表明，抗流感化合物2-(1'-氨基乙基)-双环(2.2.1)庚烷盐酸盐可降低甲型流感病毒A/MRC - 11 M蛋白的破坏作用，但对乙型流感病毒B/Lee M蛋白对线粒体呼吸的影响没有作用。
