Fedorov A N, El-Karadagi S, Rusiaev V A, Kharitonenkov I G, Tverdislov V A
Vopr Virusol. 1988 Jul-Aug;33(4):403-7.
The interaction of 2-(1'-aminoethyl)-bicyclo (2.2.1) heptane hydrochloride possessing anti-influenza activity with flat bilayer lipid membranes was studied. The compound was shown to adsorb and build-in into the lipid bilayer changing the charge, modulus of transverse elasticity, and ion permeability of the membranes. Pre-addition of the preparation into the medium washing the membrane prevents interaction of influenza virus matrix protein with the membrane. The compound also destroys M-protein aggregates in the aqueous phase. The possible role of the observed effect of the compound in its antiviral action is discussed.
研究了具有抗流感活性的2-(1'-氨基乙基)-双环(2.2.1)庚烷盐酸盐与平面双层脂质膜的相互作用。结果表明，该化合物能吸附并嵌入脂质双层，改变膜的电荷、横向弹性模量和离子通透性。在洗涤膜的介质中预先加入该制剂可防止流感病毒基质蛋白与膜相互作用。该化合物还能破坏水相中的M蛋白聚集体。讨论了该化合物观察到的效应在其抗病毒作用中的可能作用。
