Niss A I, Trubkovich M Ia, Seid-Rzaev S M
Zh Nevropatol Psikhiatr Im S S Korsakova. 1988;88(5):114-9.
An analysis of 1999 courses of psychopharmacotherapy (PPT) conducted in 90 patients with attack-like forms of schizophrenia and in 122 patients with the paranoid form has revealed an adverse effect of cerebro-organic insufficiency on PPT tolerance. In patients with the maximal degree of residual cerebro-organic insufficiency an elevated sensitivity to PPT occurred 2-2.2 times as often as in patients with a history of the minimal number of exogenously aggravated factors. PPT tolerance depended on both the nature of diseases and the age when they occurred. To evaluate the nature of pathogenic effect on the brain, all aggravating factors were divided into evidently cerebral, conditionally cerebral and other than cerebral ones. The highest intolerance was observed when evidently and conditionally cerebral aggravating factors were combined and when their combined development occurred in both early and late periods of ontogenesis.
对90例发作样型精神分裂症患者和122例偏执型患者进行的1999个精神药物治疗疗程的分析显示，脑器质性功能不全对精神药物治疗耐受性有不良影响。在残留脑器质性功能不全程度最高的患者中，对精神药物治疗的敏感性升高的发生率是外源性加重因素最少的患者的2至2.2倍。精神药物治疗耐受性取决于疾病的性质及其发病年龄。为评估对大脑的致病作用性质，将所有加重因素分为明显脑部因素、条件性脑部因素和非脑部因素。当明显和条件性脑部加重因素同时存在，且其共同发展发生在个体发育的早期和晚期时，观察到最高的不耐受性。
