Guys and St Thomas' NHS Trust, St Thomas' Hospital, London, UK.
London Northwest University Healthcare NHS Trust, London, UK.
Skeletal Radiol. 2022 Jan;51(1):171-182. doi: 10.1007/s00256-021-03821-9. Epub 2021 Jun 18.
Plain radiographs are a globally ubiquitous means of investigation for injuries to the musculoskeletal system. Despite this, initial interpretation remains a challenge and inaccuracies give rise to adverse sequelae for patients and healthcare providers alike. This study sought to address the limited, existing meta-analytic research on the initial reporting of radiographs for skeletal trauma, with specific regard to diagnostic accuracy of the most commonly injured region of the appendicular skeleton, the lower limb.
A prospectively registered, systematic review and meta-analysis was performed using published research from the major clinical-science databases. Studies identified as appropriate for inclusion underwent methodological quality and risk of bias analysis. Meta-analysis was then performed to establish summary rates for specificity and sensitivity of diagnostic accuracy, including covariates by anatomical site, using HSROC and bivariate models.
A total of 3887 articles were screened, with 10 identified as suitable for analysis based on the eligibility criteria. Sensitivity and specificity across the studies were 93.5% and 89.7% respectively. Compared with other anatomical subdivisions, interpretation of ankle radiographs yielded the highest sensitivity and specificity, with values of 98.1% and 94.6% respectively, and a diagnostic odds ratio of 929.97.
Interpretation of lower limb skeletal radiographs operates at a reasonably high degree of sensitivity and specificity. However, one in twenty true positives is missed on initial radiographic interpretation and safety netting systems need to be established to address this. Virtual fracture clinic reviews and teleradiology services in conjunction with novel technology will likely be crucial in these circumstances.
平片是一种在全球范围内普遍用于检查肌肉骨骼系统损伤的方法。尽管如此,初步解读仍然具有挑战性,并且不准确会给患者和医疗保健提供者带来不良后果。本研究旨在解决关于骨骼创伤平片初始报告的有限的、现有的荟萃分析研究,特别是关于四肢最常受伤的附肢骨骼的诊断准确性。
使用主要临床科学数据库中已发表的研究,进行了前瞻性注册的系统评价和荟萃分析。确定为适合纳入的研究进行了方法学质量和偏倚风险分析。然后使用 HSROC 和双变量模型,根据解剖部位进行荟萃分析,确定诊断准确性的特异性和敏感性的汇总率,包括协变量。
共筛选了 3887 篇文章,根据纳入标准确定了 10 篇适合分析的文章。这些研究的敏感性和特异性分别为 93.5%和 89.7%。与其他解剖细分相比,踝关节平片的解读具有最高的敏感性和特异性,分别为 98.1%和 94.6%,诊断优势比为 929.97。
下肢骨骼平片的解读具有相当高的敏感性和特异性。然而,在初始放射学解读中,每二十个真阳性就会漏诊一个,因此需要建立安全网系统来解决这个问题。虚拟骨折诊所审查和远程放射学服务以及新技术在这些情况下可能至关重要。