Jolman Scott, Robbins Justin, Lewis Laura, Wilkes Melissa, Ryan Paul
1 Madigan Army Medical Center, Tacoma, WA, USA.
2 Tripler Army Medical Center, Honolulu, HI, USA.
Foot Ankle Int. 2017 Apr;38(4):397-404. doi: 10.1177/1071100716685526. Epub 2017 Jan 6.
In patients who develop chronic ankle instability, clinicians often obtain magnetic resonance imaging (MRI) as part of the evaluation prior to operative referral. The purpose of this study was to analyze the diagnostic efficacy of MRI in the diagnosis of chronic lateral ankle instability. Our hypothesis was that magnetic resonance imaging would not be a specific diagnostic tool in the evaluation of chronic lateral ankle instability.
A retrospective chart review of 187 consecutive patients (190 ankles) was performed. Inclusion criteria for the study group required a primary complaint of instability that required operative repair or reconstruction, a documented clinical evaluation consistent with instability, stress radiographs, and MRI. Stress radiographs and clinical examinations for the study group and a control group were reviewed independently by both a musculoskeletal radiologist and a board-certified orthopaedic foot and ankle surgeon. Predictive values in terms of sensitivity, specificity, and prevalence were performed. In total, 112 patients (115 ankles) were identified who underwent an operative reconstruction of their lateral ligaments with a history, physical examination, and stress radiographs consistent with lateral ankle instability. A control group was selected consisting of 75 patients seen in the foot and ankle clinic with a diagnosis other than lateral ankle instability. Thirty-seven of the patients in the control group had stress radiographs performed in the clinic to rule out instability as part of their evaluation, and this allowed for an evaluation of the efficacy of stress radiographs in addition to MRI. Statistical analysis was performed using predictive values from sensitivity, specificity, and prevalence.
The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) in regards to MRI in the evaluation of patients found to have clinical lateral ankle instability and those who did not had statistical significance. Sensitivity of MRI was 82.6%, specificity was 53.3%, NPV was 66.7%, and PPV was 73%. Since 37 patients in the control group also had stress radiographs, a subanalysis was performed to identify the same values with stress radiographs. Sensitivity, specificity, NPV, and PPV were 66%, 97%, 48%, and 98.7%, respectively. The overall accuracy within this study was 71% for MRI and 74% for stress radiographs.
This study demonstrated that MRI has high sensitivity but low specificity in the evaluation of clinical ankle instability. While MRI has value as a screening tool for concomitant ankle pathology, it should not be considered diagnostic in terms of lateral ankle instability.
Level III, retrospective cohort, comparative series.
在出现慢性踝关节不稳的患者中,临床医生在将患者转诊至手术科室前,常将磁共振成像(MRI)作为评估的一部分。本研究的目的是分析MRI在诊断慢性外侧踝关节不稳中的诊断效能。我们的假设是,磁共振成像在评估慢性外侧踝关节不稳时并非一种特异性诊断工具。
对187例连续患者(190个踝关节)进行回顾性病历审查。研究组的纳入标准要求主要诉求为需要手术修复或重建的踝关节不稳,有记录表明临床评估与不稳相符,进行应力位X线片检查及MRI检查。研究组和对照组的应力位X线片及临床检查由一名肌肉骨骼放射科医生和一名获得委员会认证的足踝外科医生独立进行审查。计算了敏感性、特异性和患病率方面的预测值。总共确定了112例患者(115个踝关节),他们接受了外侧韧带手术重建,其病史、体格检查和应力位X线片均与外侧踝关节不稳相符。选择一个对照组,由75例在足踝门诊就诊、诊断不是外侧踝关节不稳的患者组成。对照组中有37例患者在门诊进行了应力位X线片检查以排除不稳,作为其评估的一部分,这使得除了MRI之外还能评估应力位X线片的效能。使用敏感性、特异性和患病率的预测值进行统计分析。
对于经临床诊断为外侧踝关节不稳和未诊断为外侧踝关节不稳的患者,MRI评估的敏感性、特异性、阳性预测值(PPV)和阴性预测值(NPV)具有统计学意义。MRI的敏感性为82.6%,特异性为53.3%,NPV为66.7%,PPV为73%。由于对照组中有37例患者也进行了应力位X线片检查,因此进行了亚分析以确定应力位X线片的相同值。敏感性、特异性、NPV和PPV分别为66%、97%、48%和98.7%。本研究中MRI的总体准确率为71%,应力位X线片的总体准确率为74%。
本研究表明,MRI在评估临床踝关节不稳时具有高敏感性但特异性低。虽然MRI作为一种筛查伴随踝关节病变的工具具有价值,但就外侧踝关节不稳而言,不应将其视为诊断性检查。
III级,回顾性队列研究,比较系列研究。